C0330
Ciprofibrate
别名:
2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
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关于此项目
经验公式(希尔记法):
C13H14Cl2O3
化学文摘社编号:
分子量:
289.15
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.77
表单
powder
质量水平
储存温度
2-8°C
SMILES字符串
CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O
InChI
1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
InChI key
KPSRODZRAIWAKH-UHFFFAOYSA-N
基因信息
human ... PPARA(5465)
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生化/生理作用
Peroxisome proliferator-activated receptor α (PPARα) agonist
警示用语:
Danger
危险声明
预防措施声明
危险分类
Carc. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
P Passilly et al.
Biochemical pharmacology, 58(6), 1001-1008 (1999-10-06)
The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could
Fabiana D Mendes et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2361-2368 (2011-07-19)
A rapid, sensitive and specific method for quantifying ciprofibrate in human plasma using bezafibrate as the internal standard (IS) is described. The sample was acidified prior extraction with formic acid (88%). The analyte and the IS were extracted from plasma
Zakaria El Kebbaj et al.
Endocrinology, 150(3), 1192-1201 (2008-10-25)
Seasonal obesity and fasting-associated hibernation are the two major metabolic events governing hepatic lipid metabolism in hibernating mammals. In this process, however, the role of the nuclear receptor known as peroxisome proliferator-activated receptor (PPAR)-alpha has not been elucidated yet. Here
Manfredi Rizzo et al.
Current medical research and opinion, 23(5), 1103-1111 (2007-05-24)
Beyond total low-density-lipoproteins (LDL) levels, increasing evidence suggests that the 'quality' of LDL exerts a great influence on the cardiovascular risk. Several studies have also shown that the therapeutic modulation of LDL size is of benefit in reducing the risk
Sung Hun Kim et al.
Toxicology and applied pharmacology, 215(2), 198-207 (2006-04-18)
The present study was undertaken to determine the role of the mitogen-activated protein kinase (MAPK) subfamilies in cell death induced by PPARgamma agonists in osteoblastic cells. Ciglitazone and troglitazone, PPARgamma agonists, resulted in a concentration- and time-dependent cell death, which
Chromatograms
application for HPLC
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