C0434
绒毛膜促性腺激素 人
lyophilized powder, from human pregnancy urine
别名:
HCG, 绒毛膜促性腺激素
biological source
human pregnancy urine
sterility
sterile-filtered
form
lyophilized powder
potency
~13,000 I.U. per mg
mol wt
37.9 kDa
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
solubility
water: 2 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... CGA(1081)
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General description
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
Biochem/physiol Actions
人绒毛膜促性腺激素（hCG）可用作 PMSG 的替代品，以诱导实验动物排卵。 当通过静脉内（静脉注射），腹膜内（腹腔注射）或皮下（皮下注射）方法将 hCG 注射到实验动物中时，每个动物和每千克体重的 50％ 动物的有效剂量（ED50）用括号括起来如下：
小鼠：静脉注射0.2 (7.7) I.U.；腹腔注射0.3 (11.5) I.U.；皮下注射0.7 (26.9) I.U.
叙利亚仓鼠：静脉注射1.0 (9.5) I.U.；腹腔注射1.8 (17.1) I.U.；皮下注射2.6 (24.8) I.U.
大鼠：静脉注射1.3 (4.6) I.U.；腹腔注射3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
使用 PMSG，每只动物和每千克体重（kg）的 ED50 值如下：
小鼠： 静脉注射0.8 (30.8) I.U.；腹腔注射2.0 (76.9) I.U.；皮下注射2.8 (107.7) I.U
叙利亚仓鼠： 静脉注射, 3.6 (34.3) I.U.；腹腔注射，8.0 (76.2) I.U.；皮下注射，13.2 (125.7) I.U.
大鼠： 静脉注射，6.0 (76.8) I.U.；腹腔注射，20.8 (73.0) I.U.；皮下注射，76.8 (269.5) I.U.
小鼠：静脉注射0.2 (7.7) I.U.；腹腔注射0.3 (11.5) I.U.；皮下注射0.7 (26.9) I.U.
叙利亚仓鼠：静脉注射1.0 (9.5) I.U.；腹腔注射1.8 (17.1) I.U.；皮下注射2.6 (24.8) I.U.
大鼠：静脉注射1.3 (4.6) I.U.；腹腔注射3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
使用 PMSG，每只动物和每千克体重（kg）的 ED50 值如下：
小鼠： 静脉注射0.8 (30.8) I.U.；腹腔注射2.0 (76.9) I.U.；皮下注射2.8 (107.7) I.U
叙利亚仓鼠： 静脉注射, 3.6 (34.3) I.U.；腹腔注射，8.0 (76.2) I.U.；皮下注射，13.2 (125.7) I.U.
大鼠： 静脉注射，6.0 (76.8) I.U.；腹腔注射，20.8 (73.0) I.U.；皮下注射，76.8 (269.5) I.U.
Other Notes
与 C2047 类似，但来自其他供应商。
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Nikola Sekulovski et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2376-2391 (2020-01-08)
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Tammy Z Movsas et al.
Frontiers in pediatrics, 5, 232-232 (2017-11-23)
Though the human fetus is exposed to placentally derived human chorionic gonadotropin (hCG) throughout gestation, the role of hCG on the fetal brain is unknown. Review of the available literature appears to indicate that groups of women with higher mean
Laura Riccetti et al.
Molecular human reproduction, 23(10), 685-697 (2017-10-19)
Are four urinary hCG/menotropin (hMG) and one recombinant preparation characterized by different molecular features and do they mediate specific intracellular signaling and steroidogenesis? hCG and hMG preparations have heterogeneous compositions and mediate preparation-specific cell signaling and early steroidogenesis, although similar
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