C0619
III-31-C
≥98% (HPLC), solid
别名:
N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester, WPE-III-31-C
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选择尺寸
关于此项目
经验公式（希尔记法）:
C35H52N4O7
化学文摘社编号:
分子量:
640.81
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
III-31-C, ≥98% (HPLC), solid
SMILES string
COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc2ccccc2)C(C)C
InChI
1S/C35H52N4O7/c1-23(2)19-28(31(41)38-30(24(3)4)32(42)45-8)36-33(43)39(21-26-17-13-10-14-18-26)22-29(40)27(20-25-15-11-9-12-16-25)37-34(44)46-35(5,6)7/h9-18,23-24,27-30,40H,19-22H2,1-8H3,(H,36,43)(H,37,44)(H,38,41)/t27-,28-,29+,30?/m0/s1
InChI key
DINAVFJXFRFCRE-BLFWRVEASA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: ≥9 mg/mL
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor.
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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