C0735
8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt
≥99% (HPLC), solid
别名:
Rp-8-CPT-cAMPS
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关于此项目
经验公式（希尔记法）:
C16H14ClN5O5PS2Na
化学文摘社编号:
分子量:
509.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt, ≥99% (HPLC), solid
InChI
1S/C16H15ClN5O5PS2.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-,28?;/m1./s1
SMILES string
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
InChI key
AWXMSJRRXLCVMW-JVSRKQJHSA-M
biological source
synthetic (organic)
assay
≥99% (HPLC)
form
solid
packaging
vial of 5 μmol
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist).
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Studies have shown that papaverine can inhibit lipopolysaccharide (LPS)-induced microglial activation. The retinal primary microglia of newborn SD rats were isolated and purified, and a LPS-induced microglia activation model was established. The protein phosphorylation level of the signaling pathway was
M G Weisskopf et al.
Science (New York, N.Y.), 265(5180), 1878-1882 (1994-09-23)
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression
Chad M Estep et al.
PloS one, 11(12), e0169044-e0169044 (2016-12-31)
Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors
Dongqin Yang et al.
EBioMedicine, 47, 114-127 (2019-09-10)
There are many reports of the anti-tumour effects of exogenous adenosine in gastrointestinal tumours. Gemcitabine, a first line agent for patients with poor performance status, and adenosine have structural similarities. For these reasons, it is worth exploring the therapeutic efficacy
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