C0869
南蛇藤醇
≥98% (HPLC), solid, antioxidant
别名:
10-羟基-2,4a,6a,9,12b,14a-六甲基-11-氧代-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14 b-十氢化-苉-2-羧酸, 雷公藤红素
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关于此项目
经验公式（希尔记法）:
C29H38O4
化学文摘社编号:
分子量:
450.61
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
南蛇藤醇, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
red
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O
InChI
1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChI key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
Application
使用雷公藤红素：
- 腹腔注射至试验小鼠研究其在非酒精性脂肪肝(NAFLD)中的作用
- 用在培养基中研究其对人角朊细胞培养基中脂多糖诱导的炎症损伤的影响
- 用于研究其在VCaP细胞体内和体外的作用
Biochem/physiol Actions
雷公藤红素是一种五嗪三萜烯,自然存在于雷公藤中。它对治疗类风湿性关节炎有效。雷公藤红素可阻止蛋白酶体和核因子Κb发挥作用。
雷公藤红素是一种强效抗氧化剂和抗炎剂。
雷公藤红素是一种强效抗氧化剂和抗炎剂。它是一种新的HSP90抑制剂（破坏Hsp90/Cdc37复合物），具有抗癌作用（抗血管生成-抑制血管内皮生长因子受体表达）；抗氧化剂（抑制脂质过氧化）和抗炎活性（抑制iNOS和炎性细胞因子的产生）。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
商品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C0869-10MG | 04061833452356 |
| C0869-50MG | 04061833217894 |