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Merck
CN

C0984

肌酸激酶 MB 组分 来源于人类心脏

≥70% (SDS-PAGE), liquid

别名:

CK MB组分

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关于此项目

UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00151686

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产品名称

肌酸激酶 MB 组分 来源于人类心脏, ≥70% (SDS-PAGE), liquid

biological source

human heart

assay

≥70% (SDS-PAGE)

form

liquid

concentration

≥0.5 mg/mL

technique(s)

IR spectroscopy: suitable

suitability

suitable for tissue

UniProt accession no.

P06732
P12277

application(s)

pharmaceutical

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CKB(1152), CKM(1158)

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Application

来自人心的肌酸激酶 MB 已用于：
  • 作为急性心肌梗死的诊断标志物。
  • 识别血液和心脏标志物的重叠吸收峰。
  • 研究HIV-1感染的潜在治疗药物二氧戊环鸟苷（DXG）的体内磷酸化途径。

Biochem/physiol Actions

肌酸激酶（CK）可催化从磷酸肌酸形成肌酸酐。该酶与冠状动脉性能相关。CK-MB 血清水平升高是心肌细胞损伤的主要指标，它被视作心肌梗死诊断的“金标准”。心肌肌钙蛋白 I（cTnI）或心肌肌钙蛋白 I 的水平也与 CK-MB 水平升高相关。慢性肾衰竭时 CK-MB 的水平也可能升高。

General description

研究领域：细胞信号传导
肌酸激酶（CK）由 M 和 B 亚基组成，是一种二聚体分子。它是一种 CK 同工酶。这种酶主要存在于心肌中。

Other Notes

溶于 5 mM 琥珀酸钠、10 mM 氯化钠、1 mM EDTA、5 mMβ-巯基乙醇，50% 甘油，pH 7.0。

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000514343
0000514343
0000497551
0000497551
0000441750

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the MB stand for in Product C0984, Creatine Kinase MB Fraction from human heart?

    Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
Titus J, et al.
Communications medicine, 2 (2022)
Terry M Welsh et al.
Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5?-phosphates by mammalian phosphotransferases
Feng JY, et al.
Biochemical Pharmacology, 68(9), 1879-1888 (2004)
L Gruberg et al.
The American journal of cardiology, 87(12), 1356-1360 (2001-06-09)
We evaluated the short- and long-term clinical outcomes of 326 consecutive patients with chronic renal failure, not on dialysis, who had creatine kinase (CK)-myocardial band (MB) fraction elevation after successful percutaneous coronary intervention in a native coronary artery. Based on
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