C106
CGS-12066 马来酸盐
solid
别名:
7-三氟甲基-4-（4-甲基-1-哌嗪基）吡咯并-[1,2-a]喹喔 马来酸盐
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关于此项目
经验公式（希尔记法）:
C17H17F3N4 · C4H4O4
化学文摘社编号:
分子量:
450.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H17F3N4.C4H4O4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16;5-3(6)1-2-4(7)8/h2-6,11H,7-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.CN1CCN(CC1)c2nc3cc(ccc3n4cccc24)C(F)(F)F
InChI key
ZBPAHEUAJMCLRD-BTJKTKAUSA-N
form
solid
color
white
solubility
H2O: 1.4 mg/mL, ethanol: 1.8 mg/mL, 0.1 M HCl: 4 mg/mL
Gene Information
human ... HTR1B(3351)
Biochem/physiol Actions
5-HT1B血清素受体激动剂。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Marianne Oksnes et al.
The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
Kenji Ohba et al.
PloS one, 9(5), e97787-e97787 (2014-05-27)
High prevalence of infection with high-risk human papilloma virus (HPV) ranging from 25 to 100% (average 31%) was observed in breast cancer (BC) patients in Singapore using novel DNA chip technology. Early stage of BC demonstrated higher HPV positivity, and
Mario Cioce et al.
Oncotarget, 5(12), 4129-4143 (2014-07-02)
Metabolic remodeling is a hallmark of cancer progression and may affect tumor chemoresistance. Here we investigated by 1H-NMR/PCA analysis the metabolic profile of chemoresistant breast cancer cell subpopulations (ALDHbright cells) and their response to metformin, a promising anticancer metabolic modulator.
Kevin Hollevoet et al.
Molecular cancer therapeutics, 13(8), 2040-2049 (2014-06-15)
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. RG7787 is a novel low-immunogenic antimesothelin recombinant immunotoxin (RIT), engineered to overcome the limitations of SS1P, a RIT now in clinical trials. In vitro activity was evaluated
Mattia Bramini et al.
ACS nano, 8(5), 4304-4312 (2014-04-30)
Understanding nanoparticle interactions with the central nervous system, in particular the blood-brain barrier, is key to advances in therapeutics, as well as assessing the safety of nanoparticles. Challenges in achieving insights have been significant, even for relatively simple models. Here
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