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Merck
CN

C11100P

DMT-dC(bz) Pharmadite®

别名:

DMT-dC(bz) Phosphoramidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite]

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关于此项目

经验公式（希尔记法）:
C46H52N5O8P
分子量:
833.91
NACRES:
NA.51
PubChem Substance ID:
329774847
UNSPSC Code:
12352200
MDL number:
MFCD00036315
Assay:
≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)
Biological source:
non-animal source (no BSE/TSE risk)
Form:
powder or granules
Solubility:
soluble, clear
Storage temp.:
2-8°C

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InChI key

PGTNFMKLGRFZDX-SALLYJDFSA-N

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1

biological source

non-animal source (no BSE/TSE risk)

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

>= 170ppm, none detected (S/N <2.5), ≤0.1% single unspecified Imprity (reversed phase HPLC), ≤0.3% P(III) 100-169ppm (31P-NMR), ≤0.3% dC2 (reversed phase HPLC, DMT-dC(bz) cyanoethyl-H-posphonate), ≤0.3% dC3 (reversed phase HPLC, DMT-dC(bz) phosphoramidate), ≤0.3% dC5 (reversed phase HPLC, O3′-Benzoyl-O5′-DMT-dC(bz)), ≤0.30 wt. % water content (Karl Fischer), ≤0.5% P(V) -25-99ppm (31P-NMR), ≤3.0 wt. % residual solvent content

color

white to off-white

solubility

soluble, clear

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: deoxycytidine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

Quality Level

300

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General description

DMT-dC(bz) Pharmadite® is a Pharmadite® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity.Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free fromcontaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remainingimpurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Legal Information

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
HMBK7808
HMBK7267
HMBK5841
HMBK5765
HMBK1055

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