Merck
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文件

C1129

Sigma-Aldrich

胆酸

from bovine and/or ovine, ≥98%

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别名:
3α,7α,12α-三羟基-5β-胆烷酸, 胆烷酸
经验公式（希尔记法）:
C24H40O5
CAS号:
81-25-4
分子量:
408.57
Beilstein:
2822009
EC 号:
201-337-8
MDL编号:
MFCD00003672
PubChem化学物质编号:
24892356
NACRES:
NA.25

生物来源

bovine and/or ovine

质量水平

200

描述

anionic

检测方案

≥98%

形式

powder

分子量

408.57 g/mol

mp

200-201 °C (lit.)

官能团

carboxylic acid

运输

ambient

储存温度

room temp

SMILES string

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O

InChI

1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

InChI key

BHQCQFFYRZLCQQ-OELDTZBJSA-N

Gene Information

human ... CYP1A2(1544)

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相关类别

一般描述

胆酸是肝脏中产生的主要的胆汁酸，其可促进脂肪吸收和胆固醇排泄。 它是一种非变性离子型去污剂。

应用

在一项研究中，膳食胆酸已被用于评估其对结肠上皮细胞增殖的影响。 它也被用于研究人类红细胞血影的提取和比较。
用于提取膜蛋白的非变性离子洗涤剂。

生化/生理作用

胆汁酸

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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E E Deschner et al.
Digestion, 21(6), 290-296 (1981-01-01)
Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed
R Coleman et al.
Biochimica et biophysica acta, 436(1), 38-44 (1976-06-04)
1. Human erythrocyte ghosts were extracted with individual free and conjugated bile salts and, for comparison, with Triton X-100 under conditions approximating to physiological temperature, pH and tonicity. 2. Treatment with cholate, glycocholate, taurocholate, or with Triton X-100 gave lipid-depleted
Hui Zhou et al.
JCI insight, 5(20) (2020-10-16)
High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis. We found that HFF resulted in widespread taxonomic
Michael Lazarou et al.
The FEBS journal, 276(22), 6701-6713 (2009-10-22)
Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial
Roberto Pellicciari et al.
Journal of medicinal chemistry, 50(18), 4265-4268 (2007-08-10)
23-Alkyl-substituted and 6,23-alkyl-disubstituted derivatives of chenodeoxycholic acid are identified as potent and selective agonists of TGR5, a G-protein coupled receptor for bile acids (BAs). In particular, we show that methylation at the C-23(S) position of natural BAs confers a marked
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