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Merck
CN

C1131

胞苷 5′-一磷酸

≥99% (HPLC), synthetic, powder

别名:

5′-CMP, 5′-胞苷酸, C-5′-P

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关于此项目

经验公式（希尔记法）:
C9H14N3O8P
化学文摘社编号:
63-37-6
分子量:
323.20
NACRES:
NA.51
PubChem Substance ID:
24892358
UNSPSC Code:
41106305
EC Number:
200-556-6
MDL number:
MFCD00006544
Beilstein/REAXYS Number:
46982

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产品名称

胞苷 5′-一磷酸, Sigma Grade, ≥99% (HPLC), synthetic, powder

InChI key

IERHLVCPSMICTF-XVFCMESISA-N

InChI

1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

SMILES string

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O

biological source

synthetic

grade

Sigma Grade

assay

≥99% (HPLC)

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

胞苷5′-单磷酸已用于拉曼光谱研究。

Biochem/physiol Actions

核苷二磷酸胞苷二磷酸(CDP)和尿苷二磷酸(UDP)是合成嘧啶的必需组分胞苷5′-单磷酸(CMP)核苷酸用于仿生磷灰石的吸附研究，用于模拟骨骼矿物质。它也可用作儿科制剂中的免疫增强剂。
胞苷5′-单磷酸 (CMP) 作为单磷酸尿苷 (UMP)/单磷酸胞苷 (CMP) 激酶（酶代码 EC 2.7.4.4）的底物形成 CDP，CDP 经磷酸化形成 CTP，支持 DNA 和 RNA 的生物合成。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000519723
0000519723
0000509982
0000509987
0000509982

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A Hirono et al.
Clinica chimica acta; international journal of clinical chemistry, 130(2), 189-197 (1983-05-30)
Three new variants of pyrimidine 5'-nucleotidase (P5N) found in Japan were studied. They are characterized by slow electrophoretic mobility and a high Michaelis constant for cytidine 5'-monophosphate as has been described in previously reported cases, but are unique with respect
Linda J Reha-Krantz et al.
Biochemistry, 50(46), 10136-10149 (2011-10-26)
The adenine base analogue 2-aminopurine (2AP) is a potent base substitution mutagen in prokaryotes because of its enhanceed ability to form a mutagenic base pair with an incoming dCTP. Despite more than 50 years of research, the structure of the
Haifeng C Xu et al.
Journal of virology, 89(9), 4748-4759 (2015-02-13)
The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using BAFF receptor
Sarah Schott et al.
International journal of cancer, 131(9), 2165-2174 (2012-02-11)
Melanoma is an increasingly common and potentially fatal malignancy of the skin and some mucous membranes. As no cure exists for metastatic disease, there is an urgent need for novel drugs. 2'-Deoxy-5-fluorouridylyl-(3'-5')-3'-C-ethynylcytidine [5-FdU(3'-5')ECyd] and 3'-C-ethynylcytidinylyl-(5' → 1-O)-2-O-octadecyl-sn-glycerylyl-(3-O → 5')-2'-deoxy-5-fluorouridine [ECyd-lipid-5-FdU]
An enzymatic alternative for the synthesis of nucleoside 5?-monophosphates
Gudino ED, et al.
Enzyme and Microbial Technology, 111, 1-6 (2018)
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实验方案

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

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