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C1159

环丝氨酸

Name: <SC/>环丝氨酸
Brand: SIGMA

≥95% (TLC), ketosphinganine synthetase inhibitor, powder

别名:

(S)-4-Amino-3-isoxazolidone

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关于此项目

经验公式（希尔记法）:

C₃H₆N₂O₂

化学文摘社编号:

339-72-0

分子量:

102.09

NACRES:

NA.77

PubChem Substance ID:

24278296

eCl@ss:

32160406

UNSPSC Code:

12352202

EC Number:

206-427-0

MDL number:

MFCD00064324

Beilstein/REAXYS Number:

80799

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产品名称

环丝氨酸,

assay

≥95% (TLC)

Quality Level

200

form

powder

mp

146 °C

solubility

H₂O: 50 mg/mg protein

storage temp.

−20°C

SMILES string

N[C@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1

InChI key

DYDCUQKUCUHJBH-REOHCLBHSA-N

Biochem/physiol Actions

Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Cytotoxicity of L-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression.

J Cinatl et al.

Anticancer research, 19(6B), 5349-5354 (2000-03-04)

Human neuroblastoma and medulloblastoma express abnormal ganglioside patterns especially GD2 and GM2 which are important for tumour growth. We tested the effects of L-cycloserine (L-CS), a potent inhibitor of synthesis of glycosphingolipids, on the growth, viability and expression of GD2

Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells.

David M Pereira et al.

Marine drugs, 12(1), 54-68 (2013-12-26)

We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a

An Analysis of Clostridium difficile Environmental Contamination During and After Treatment for C difficile Infection.

Kerrie Davies et al.

Open forum infectious diseases, 7(11), ofaa362-ofaa362 (2020-11-19)

Lower Clostridium difficile spore counts in feces from C difficile infection (CDI) patients treated with fidaxomicin versus vancomycin have been observed. We aimed to determine whether environmental contamination is lower in patients treated with fidaxomicin compared with those treated with

De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma.

Geraldine Rath et al.

The international journal of biochemistry & cell biology, 41(5), 1165-1172 (2008-11-26)

Doxorubicin and camptothecin are two cytotoxic chemotherapeutic agents triggering apoptosis in various cancer cells, including thyroid carcinoma cells. Recent studies revealed a critical role of ceramide in chemotherapy and suggested that anti-cancer drugs may kill tumor cells through sphingomyelinase activation.

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4.

Domenico Sergi et al.

Nutritional neuroscience, 23(4), 321-334 (2018-07-24)

A high-fat diet induces hypothalamic inflammation in rodents which, in turn, contributes to the development of obesity by eliciting both insulin and leptin resistance. However, the mechanism by which long-chain saturated fatty acids trigger inflammation is still contentious. To elucidate

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全球贸易项目编号

货号	GTIN
C1159-25MG	04061832940977
C1159-10MG	04061832940953
C1159-250MG	04061832940960
C1159-100MG	04061832940946

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