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Merck
CN

C1172

Sigma-Aldrich

ML-9

≥99% (TLC), powder

别名:

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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关于此项目

线性分子式:
C15H17N2O2SCl · HCl
化学文摘社编号:
105637-50-1
分子量:
361.29
MDL编号:
MFCD00065525
UNSPSC代码:
12352202
PubChem化学物质编号:
24278297
NACRES:
NA.77

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生物来源

synthetic (organic)

方案

≥99% (TLC)

表单

powder

颜色

white

溶解性

ethanol: 10 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI key

ZNRYCIVTNLZOGI-UHFFFAOYSA-N

基因信息

human ... SLC2A1(6513), SLC2A4(6517)

应用

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

生化/生理作用

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

特点和优势

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCD5569
SLCD0376
SLBV3170
SLBQ2883V
SLBP4607V

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The adrenal medulla (1992)
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes.
Inoue G, et al.
The Journal of Biological Chemistry, 268(7), 5272-5278 (1993)
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
AntoineTE and Shukla D
Antiviral Therapy, 19(1), 15-29 (2014)
Amy Peng et al.
Neuron, 73(6), 1108-1115 (2012-03-27)
Synaptic vesicle exo- and endocytosis are usually driven by neuronal activity but can also occur spontaneously. The identity and differences between vesicles supporting evoked and spontaneous neurotransmission remain highly debated. Here we combined nanometer-resolution imaging with a transient motion analysis
B G Garcia et al.
Molecular pharmacology, 68(1), 102-109 (2005-03-30)
Uptake by the dopamine transporter (DAT) is the primary pathway for the clearance of extracellular dopamine (DA) and consequently for regulating the magnitude and duration of dopaminergic signaling. Amphetamine (AMPH) has been shown to decrease simultaneously DAT cell-surface expression and
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