C1230
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone
≥90% (TLC), powder
别名:
Z-IETD-FMK
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C30H43FN4O11
化学文摘社编号:
分子量:
654.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
产品名称
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone, ≥90% (TLC), powder
InChI
1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
SMILES string
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI key
CTXDBLYOEUERAT-VUVYEONESA-N
biological source
synthetic (organic)
assay
≥90% (TLC)
form
powder
solubility
methanol: 10 mg/mL
DMSO: 20 mM, clear, colorless to light yellow
shipped in
dry ice
storage temp.
−20°C
Quality Level
Application
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
- to study the activity of caspase-8 in porcine kidney cells
- to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
- to study its effects on retinal ganglion and astroglia in rat eyes
Biochem/physiol Actions
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Lina Hu et al.
Journal of the American Heart Association, 8(24), e005886-e005886 (2019-12-17)
Background Although apoptosis and cell proliferation have been extensively investigated in atherosclerosis and restenosis postinjury, the communication between these 2 cellular events has not been evaluated. Here, we report an inextricable communicative link between apoptosis and smooth muscle cell proliferation
Yanjie Kong et al.
International journal of cancer, 145(5), 1371-1381 (2019-02-27)
The Cullin 7 (CUL7) gene encodes a member of the cullin family of E3 ubiquitin ligases. Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves cancer cell survival has not been fully elucidated. Here, we
Tina M Sauerwald et al.
Biotechnology and bioengineering, 81(3), 329-340 (2002-12-11)
Apoptosis in mammalian cell culture is associated with decreased bioproduct yields and can be inhibited through altering the intracellular signaling pathways mediating programmed cell death. In this study, we evaluated the capacity to inhibit caspases to maintain high viable cell
Guo-Hua Qiu et al.
Cytotechnology, 71(1), 23-33 (2019-01-05)
The tumor suppressor DLEC1 has been shown to promote cell proliferation when AP-2α2 is down-regulated in HCT116 stable clones, suggesting its pro-survival nature. However, the pro-survival function of DLEC1 has not been confirmed in other cells and its underlying mechanisms
Yang Liu et al.
Frontiers in cell and developmental biology, 8, 608-608 (2020-08-01)
Polypoidal choroidal vasculopathy (PCV) is the predominant subtype of exudative age-related macular degeneration in Asians. Although photodynamic therapy (PDT) is widely used for PCV treatment, its long-term beneficial effects are unsatisfactory. Accumulating clinical investigations suggest that combined therapy with anti-vascular
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持