C144
1-（3-氯苯基）双胍 盐酸盐
solid
别名:
1-（间氯苯基）双胍 盐酸盐, N-（3-氯苯基）亚氨基二碳亚胺二酰胺 盐酸盐, m-CPBG 盐酸盐
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关于此项目
线性分子式:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
化学文摘社编号:
分子量:
248.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
SMILES string
Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1
InChI key
FOWAIJYHRWFTHR-UHFFFAOYSA-N
form
solid
color
white
mp
190-194 °C (lit.)
solubility
H2O: soluble
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
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Biochem/physiol Actions
非常强效的5-HT35-羟色胺受体激动剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Gloves
Zachary A Rodd et al.
The Journal of pharmacology and experimental therapeutics, 321(3), 1003-1012 (2007-02-28)
Studies from our laboratory indicated that local perfusion of the ventral tegmental area (VTA) with a serotonin-3 (5-HT(3)) receptor agonist increased dopamine (DA) neuronal activity and that the self-infusion of ethanol (EtOH) and cocaine into the posterior VTA could be
Borna Payandemehr et al.
Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
G J Kilpatrick et al.
European journal of pharmacology, 182(1), 193-197 (1990-06-21)
1-(m-Chlorophenyl)-biguanide (mCPBG) was examined and compared with three 5-HT3 receptor agonists in three 5-HT3 receptor models. mCPBG inhibited [3H]GR67330 binding to 5-HT3 receptors with high affinity (IC50 1.5 nM). mCPBG depolarized the rat vagus nerve with an EC50 one tenth
Jaime M Monti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(4), 940-947 (2008-02-26)
The effects of the selective 5-HT(3) receptor agonist and antagonist m-chlorophenylbiguanide (m-CPBG) and ondansetron, respectively, were studied in adult male Wistar rats implanted for chronic sleep recordings. Microinjection of m-CPBG (2.0 and 4.0 mM) into the dorsal raphe nucleus (DRN)
Philip M Lang et al.
Journal of neurophysiology, 96(6), 2963-2971 (2006-09-08)
Activity-dependent fluctuations in axonal excitability and changes in interspike intervals modify the conduction of trains of action potentials in unmyelinated peripheral nerve fibers. During inflammation of a nerve trunk, long stretches of axons are exposed to inflammatory mediators such as
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