C1530
Cyclopiazonic acid
from Penicillium cyclopium, ≥98% (HPLC), powder, sarcoplasmic reticulum Ca²⁺-pump inhibitor
别名:
CPA
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关于此项目
经验公式（希尔记法）:
C20H20N2O3
化学文摘社编号:
分子量:
336.38
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
产品名称
环盐酸吗甲吡嗪酸 来源于圆弧青霉菌, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: soluble
chloroform: soluble
储存温度
−20°C
SMILES字符串
CN1C(=O)C(=C(\C)O)\C(=O)C2C(Cc3cccc4[nH]cc2c34)C1(C)C
InChI
1S/C20H22N2O3/c1-10(23)15-18(24)17-12-9-21-14-7-5-6-11(16(12)14)8-13(17)20(2,3)22(4)19(15)25/h5-7,9,13,17,21,23H,8H2,1-4H3/b15-10-
InChI key
WJCPGKDPOYBOOJ-GDNBJRDFSA-N
基因信息
human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
相关类别
一般描述
圆弧偶氮酸（CPA）是由多种 曲霉 和 青霉菌 种合成的tetramic酸。
应用
圆弧青霉菌来源圆弧偶氮酸用于：
- 作为标准品，用于薄层色谱法（TLC）检测和定量黄曲霉毒素
- 作为培养基成分，用于不含Ca2+的DMEM（含10％胎牛血清（FBS））
- 作为肌质网/内质网Ca2+ -ATP酶的可逆抑制剂，检测腔内钙在内质网（ER）-至-高尔基体转运过程中的作用
- 作为内质网Ca2+-ATP酶的阻滞剂，处理神经元；研究内质网（ER）在Ca2+诱导的Ca2+ 释放（CICR）抑制 SERCA 过程中，对释放和维持Ca2+ 的影响
生化/生理作用
抑制肌质网 Ca 2 + -泵。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
G W J Wright et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(5), e221-e234 (2012-02-02)
Interstitial cells of Cajal (ICC) associated with the myenteric plexus of the small intestine express maxi chloride channels. Our aim was to investigate whether or not these channels would be activated by increases in intracellular Ca(2+) , as that would
Sakiko Ujita et al.
Cerebral cortex (New York, N.Y. : 1991), 27(2), 1602-1614 (2016-01-24)
Astrocytes in various brain regions exhibit spontaneous intracellular calcium elevations both in vitro and in vivo; however, neither the temporal pattern underlying this activity nor its function has been fully evaluated. Here, we utilized a long-term optical imaging technique to
N Demaurex et al.
The Journal of biological chemistry, 267(4), 2318-2324 (1992-02-05)
The filling state of intracellular Ca2+ stores has been proposed to regulate Ca2+ influx across the plasma membrane in a variety of tissues. To test this hypothesis, we have used three structurally unrelated inhibitors of the Ca(2+)-ATPase of intracellular Ca2+
Plant and fungal toxins as contaminants of feed and meat
Improving the Safety of Fresh Meat, 77-101 (2005)
Ca2+-Induced Ca2+ Release in Aplysia Bag Cell Neurons Requires Interaction Between Mitochondrial and Endoplasmic Reticulum Stores
Geiger JE, et al.
Journal of Neurophysiology (2008)
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