C1671
氯普噻吨 盐酸盐
别名:
2-氯-9-（3-二甲基氨基亚丙基）噻吨 盐酸盐
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关于此项目
经验公式（希尔记法）:
C18H18ClNS · HCl
化学文摘社编号:
分子量:
352.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
229-289-3
MDL number:
Form:
powder
InChI key
YWKRLOSRDGPEJR-KIUKIJHYSA-N
InChI
1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;
SMILES string
Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13
form
powder
storage temp.
2-8°C
Gene Information
human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)
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General description
氯普噻吨为精神安定药，属噻吨类。它具有抗胆碱药作用。氯普噻吨可能与梗阻性黄疸和帕金森综合征有关。用于治疗精神病。
Application
用盐酸氯普噻吨研究了其暴露对大鼠学习和记忆的影响。
Biochem/physiol Actions
D2多巴胺受体拮抗剂；阻断大鼠皮层中GABAA受体的一个子集，该子集也被氯氮平阻断；硫黄嘌呤类抗精神病药。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Desk Reference of Clinical Pharmacology, Second Edition (1997)
Manavu Tohmi et al.
iScience, 26(1), 105778-105778 (2023-01-04)
Despite its importance, the development of higher visual areas (HVAs) at the cellular resolution remains largely unknown. Here, we conducted 2-photon calcium imaging of mouse HVAs lateromedial (LM) and anterolateral (AL) and V1 to observe developmental changes in visual response
V Hadjimitova et al.
Pharmacology & toxicology, 84(4), 170-173 (1999-05-05)
The effect of some psychotropic drugs on the activity of macrophages to produce superoxide radicals during phagocytosis was tested. Three-cyclic antidepressants, imipramine and amitriptyline, and the thioxanthene neuroleptic, chlorprothixene, were studied. The superoxide production was measured by luminol-dependent chemiluminescence. The
M Froimowitz et al.
Journal of medicinal chemistry, 36(15), 2219-2227 (1993-07-23)
Conformational analyses have been performed on several phenothiazine and thioxanthene dopamine antagonists using the MM2-87 program and parameter set. The compounds that were examined are thioridazine (2), methotrimeprazine (3), cis- and trans-chlorprothixene, and a piperidylidene derivative of chlorprothixene. In addition
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