C1671
氯普噻吨 盐酸盐
别名:
2-氯-9-（3-二甲基氨基亚丙基）噻吨 盐酸盐
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经验公式（希尔记法）:
C18H18ClNS · HCl
化学文摘社编号:
分子量:
352.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
229-289-3
MDL number:
Form:
powder
InChI key
YWKRLOSRDGPEJR-KIUKIJHYSA-N
InChI
1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;
SMILES string
Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13
form
powder
storage temp.
2-8°C
Gene Information
human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)
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Application
用盐酸氯普噻吨研究了其暴露对大鼠学习和记忆的影响。
Biochem/physiol Actions
D2多巴胺受体拮抗剂；阻断大鼠皮层中GABAA受体的一个子集，该子集也被氯氮平阻断；硫黄嘌呤类抗精神病药。
General description
氯普噻吨为精神安定药，属噻吨类。它具有抗胆碱药作用。氯普噻吨可能与梗阻性黄疸和帕金森综合征有关。用于治疗精神病。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Manavu Tohmi et al.
iScience, 26(1), 105778-105778 (2023-01-04)
Despite its importance, the development of higher visual areas (HVAs) at the cellular resolution remains largely unknown. Here, we conducted 2-photon calcium imaging of mouse HVAs lateromedial (LM) and anterolateral (AL) and V1 to observe developmental changes in visual response
V Hadjimitova et al.
Pharmacology & toxicology, 84(4), 170-173 (1999-05-05)
The effect of some psychotropic drugs on the activity of macrophages to produce superoxide radicals during phagocytosis was tested. Three-cyclic antidepressants, imipramine and amitriptyline, and the thioxanthene neuroleptic, chlorprothixene, were studied. The superoxide production was measured by luminol-dependent chemiluminescence. The
M Froimowitz et al.
Journal of medicinal chemistry, 36(15), 2219-2227 (1993-07-23)
Conformational analyses have been performed on several phenothiazine and thioxanthene dopamine antagonists using the MM2-87 program and parameter set. The compounds that were examined are thioridazine (2), methotrimeprazine (3), cis- and trans-chlorprothixene, and a piperidylidene derivative of chlorprothixene. In addition
Joshua B Melander et al.
Cell reports, 37(6), 109972-109972 (2021-11-11)
Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
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