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Merck
CN

C171

氯氮平标准液

solid

别名:

8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]二氮杂卓

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关于此项目

经验公式(希尔记法):
C18H19ClN4
化学文摘社编号:
分子量:
326.82
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
227-313-7
MDL number:
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form

solid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

pale yellow

solubility

ethanol: 11 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL

format

neat

SMILES string

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

QZUDBNBUXVUHMW-UHFFFAOYSA-N

Gene Information

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

非典型抗精神病药,对 D4 多巴胺受体比对 D2 或 D3 多巴胺受体表现出更大的亲和性;在用典型抗精神病药无效的患者中,对精神分裂症的阳性和阴性症状均表现出抗精神病疗效。

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分析证书(COA)

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Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV-associated tumor progression. Novel nonpeptidergic chemotypes were identified as
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Journal of medicinal chemistry, 52(1), 151-169 (2008-12-17)
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Rogier A Smits et al.
Journal of medicinal chemistry, 49(15), 4512-4516 (2006-07-21)
A series of dibenzodiazepine derivatives was synthesized to probe the binding site of the recently discovered histamine H4 receptor (H4R). Optimization of the lead structure clozapine (2) resulted in (E)-7-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine (7j), a potent H4R agonist (H4R, pKi = 7.6). Pharmacological
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