C209
Clobenpropit dihydrobromide
solid
别名:
VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide
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关于此项目
经验公式（希尔记法）:
C14H17ClN4S · 2HBr
化学文摘社编号:
分子量:
470.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
产品名称
Clobenpropit dihydrobromide, solid
InChI
1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H
SMILES string
Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1
InChI key
JIJQPEZAVLJZBO-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: >20 mg/mL
ethanol: 3.30 mg/mL
DMSO: >30 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
Disclaimer
Hygroscopic
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
W Bäumer et al.
Allergy, 63(10), 1387-1394 (2008-09-11)
Dendritic cells (DC) are the major antigen-presenting cells and play a key role in adaptive immunity as they are able to activate naive T cells. It was recently described, that the histamine H(4) receptor (H4R) is present on human monocyte-derived
Brajesh K Rai et al.
Proteins, 78(2), 457-473 (2009-09-30)
G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that play important role in regulating key physiological functions, and are targets of about 50% of all recently launched drugs. High-resolution experimental structures are available only for very few GPCRs. As a
Fanyin Meng et al.
Hepatology (Baltimore, Md.), 54(5), 1718-1728 (2011-07-28)
Cholangiocarcinoma (CCA) is a biliary cancer arising from damaged bile ducts. Epithelial-mesenchymal transition (EMT) occurs as epithelial cells begin to resemble mesenchymal cells leading to increased invasion potential as the extracellular matrix (ECM) degrades. Histamine exerts its effects by way
Kasper B Hansen et al.
The Journal of pharmacology and experimental therapeutics, 333(3), 650-662 (2010-03-04)
N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity, neuronal development, and several neurological diseases. We describe a fluorescence-based
Danish Mahmood et al.
Pharmacological reports : PR, 64(1), 191-204 (2012-05-15)
Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain histaminergic neuronal system involvement in the pathogenesis of psychotic disorders including SCZ.
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