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Merck
CN

C2175

（酪氨酸[SO3H]27）胆囊收缩素片段26-33酰胺

≥97% (HPLC), powder

别名:

CCK-8, 促胰酶素C-末端八肽, 八肽胆囊收缩素, 辛卡利特

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关于此项目

经验公式（希尔记法）:
C49H62N10O16S3
化学文摘社编号:
25126-32-3
分子量:
1143.27
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
24892470
EC Number:
246-639-0
Beilstein/REAXYS Number:
5231801
MDL number:
MFCD00079849

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产品名称

（酪氨酸[SO3H]27）胆囊收缩素片段26-33酰胺, ≥97% (HPLC), powder

InChI key

IZTQOLKUZKXIRV-IVVJSLGPSA-N

InChI

1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35?,36-,37-,38-,39-/m0/s1

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P06307
P30551
P30553

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CCK(885)
rat ... Cckar(24889), Cckbr(25706)

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Application

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺已用于：
  • 研究其对胰腺炎中β5i/LMP7免疫蛋白酶体亚基的作用
  • 检测其对小窝(SL)和正常(NL)大鼠的胃排空、食物摄入和c-Fos免疫反应性的影响
  • 检测其对贝氏隆头鱼(Ballan Wrasse)肠和胆囊运动的影响

Biochem/physiol Actions

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺可激活胆囊收缩素B受体，介导阿片类药物镇痛的抑制作用。具有抗炎作用。介导对细胞因子释放、淋巴细胞和巨噬细胞的抑制作用。
神经递质；中枢神经系统和胃肠道中CCK的主要形式；可能会在饱腹感中发挥作用。

General description

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺是由proCCK加工获得的八肽胆囊收缩素(CCK)硫酸盐。它存在于血浆和内分泌细胞中。

Other Notes

胆囊收缩素的C末端八肽

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000484337
0000484337
0000478834
0000478834
0000481286

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