C221
羧基-PTIO 钾盐
synthetic (organic), ≥98% (TLC), NO scavenger, powder
别名:
2-（4-羧基苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物 钾盐, 2-（4-羧基苯基）-4,5-二氢-4,4,5,5-四甲基-1H-咪唑-1-基氧基-3-氧化物 钾盐
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关于此项目
经验公式（希尔记法）:
C14H16KN2O4
CAS Number:
分子量:
315.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
Product Name
羧基-PTIO 钾盐,
生物来源
synthetic (organic)
质量水平
方案
≥98% (TLC)
表单
powder
mp
>270 °C
溶解性
H2O: 100 mg/mL
DMSO: soluble (lit.)(lit.)
methanol: soluble (lit.)(lit.)
储存温度
2-8°C
SMILES字符串
[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
InChI
1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
InChI key
VYEUQMVIGXFZQU-UHFFFAOYSA-M
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一般描述
2-（4-羧苯基）-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物（羧基-PTIO）主要被认为是一氧化氮（NO）清除剂。
应用
羧基-PTIO钾盐通过检查反应混合物中羟基自由基或硝酸的生成情况，确定反应混合物中一氧化氮的生成情况。还可添加至神经元，分析其对葡萄糖/氧气/血清剥夺（GOSD）状态的影响（4）
生化/生理作用
其与一氧化氮反应可形成羧基-PTI衍生物，产物可进一步抑制一氧化氮合成酶的活性。
羧基-PTIO可以与一氧化氮（NO）快速反应生成二氧化氮（NO2）。 可用于预防 体内脂多糖刺激引起的低血压和内毒素性休克。羧基-PTIO还可以阻断 体外 NO刺激造成的血管松弛。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nitric oxide scavenger carboxy-PTIO potentiates the inhibition of dopamine uptake by nitric oxide donors
Cao B J and Reith M EA
European Journal of Pharmacology, 448(1), 27-30 (2002)
Raymond N Allan et al.
Nitric oxide : biology and chemistry, 65, 43-49 (2017-02-27)
Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve anti-biofilm efficacy and support reduction in antibiotic use. Treatment
Megumi Hada et al.
International journal of molecular sciences, 20(18) (2019-09-07)
Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human
Anton Misak et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-27)
Doxycycline (DOXY) is an antibiotic routinely prescribed in human and veterinary medicine for antibacterial treatment, but it has also numerous side effects that include oxidative stress, inflammation, cancer or hypoxia-induced injury. Endogenously produced hydrogen sulfide (H₂S) and polysulfides affect similar
M Yoshida et al.
Biochemical and biophysical research communications, 202(2), 923-930 (1994-07-29)
We recently found a new class of nitric oxide (NO) antidote, i.e., 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide derivatives (PTIOs). It has a potent inhibitory action against endothelium-derived relaxing factor. Here, we report the effect of a water-soluble carboxy derivative of PTIO (carboxy-PTIO) on endotoxin
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