C2247
CPPHA
≥98% (HPLC)
别名:
N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide, N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
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关于此项目
经验公式（希尔记法）:
C22H15ClN2O4
化学文摘社编号:
分子量:
406.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
InChI
1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
SMILES string
Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
InChI key
UFOUABRZSDGGAZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: >20 mg/mL
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.
−20°C
Biochem/physiol Actions
CPPHA is a positive allosteric modulator of mGluR5 receptor.
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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