Application
48/80化合物可用来：
- 刺激血细胞释放组胺，从而通过ELISA和流式细胞仪测定
- 诱发肥大细胞脱粒
- 诱发小鼠过敏性活动、皮炎、瘙痒和炎症
Biochem/physiol Actions
化合物48/80是一种低血压药，促进组胺释放。C 48/80降低了 Styela plicata血细胞的吞噬能力。C 48/80 促进肥大细胞脱粒。它抑制钙调蛋白，磷脂酶C，内质网（ER）Ca2+磷酸酶和激活G蛋白。
General description
化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。
Preparation Note
N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
Histamine regulates the inflammatory response of the tunicate Styela plicata
Garcia-Garcia E, et al.
Developmental and Comparative Immunology, 46(2), 382-391 (2014)
C Bronner et al.
Biochimica et biophysica acta, 920(3), 301-305 (1987-08-15)
Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly stimulated Ca2+-dependent phospholipase A2, higher concentrations led to dose-dependent inhibition of this platelet enzyme. This biphasic effect was confirmed with phospholipases A2 purified
Antiallergic activity of Aristolochia bracteolata Lank in animal model
Chitme HR, et al.
Indian Journal of Experimental Biology, 48, 46-52 (2010)
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
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