相关类别
一般描述
化合物48/80,是一种N-甲基p-甲氧基苯乙基胺和甲醛缩合产物。
应用
48/80化合物可用来：
- 刺激血细胞释放组胺，从而通过ELISA和流式细胞仪测定
- 诱发肥大细胞脱粒
- 诱发小鼠过敏性活动、皮炎、瘙痒和炎症
生化/生理作用
化合物48/80是一种低血压药，促进组胺释放。C 48/80降低了 Styela plicata血细胞的吞噬能力。C 48/80 促进肥大细胞脱粒。它抑制钙调蛋白，磷脂酶C，内质网（ER）Ca2+磷酸酶和激活G蛋白。
制备说明
N-甲基-p-甲氧基苯乙基胺和甲醛缩合产物。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
C Bronner et al.
Biochimica et biophysica acta, 920(3), 301-305 (1987-08-15)
Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly stimulated Ca2+-dependent phospholipase A2, higher concentrations led to dose-dependent inhibition of this platelet enzyme. This biphasic effect was confirmed with phospholipases A2 purified
Antiallergic activity of Aristolochia bracteolata Lank in animal model
Chitme HR, et al.
Indian Journal of Experimental Biology, 48, 46-52 (2010)
Histamine regulates the inflammatory response of the tunicate Styela plicata
Garcia-Garcia E, et al.
Developmental and Comparative Immunology, 46(2), 382-391 (2014)
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
Byrne RD, et al.
Cellular Signalling, 19(2), 321-329 (2007)
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