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C2365

Clofilium tosylate

Name: Clofilium tosylate
Brand: SIGMA

>97%, K+channel blocker, solid

别名:

4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate

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关于此项目

经验公式（希尔记法）:

C₂₁H₃₇ClN · C₇H₇O₃S

化学文摘社编号:

92953-10-1

分子量:

510.17

UNSPSC Code:

12352200

PubChem Substance ID:

24892319

NACRES:

NA.77

MDL number:

MFCD00069233

Assay:

>97%

Form:

solid

Quality level:

100

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产品名称

Clofilium tosylate, >97%, solid

Quality Level

100

assay

>97%

form

solid

color

white

solubility

H₂O: soluble

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc2ccc(Cl)cc2

InChI

1S/C21H37ClN.C7H8O3S/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-6-2-4-7(5-3-6)11(8,9)10/h14-17H,4-13,18-19H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key

MOQZYUUHIWPDQC-UHFFFAOYSA-M

Biochem/physiol Actions

K⁺ channel blocker; cardiac depressant; anti-arrhythmic

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

wgk

WGK 3

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.

H Papp et al.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 67(5), 731-737 (2016-12-25)

Hyperventilation reduces partial pressure of CO

Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells.

Sean A Misek et al.

Molecular pharmacology, 101(1), 1-12 (2021-11-05)

Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal of this study was to use an unbiased computational

A voltage-dependent K

Wuyang Wang et al.

The Journal of cell biology, 216(6), 1715-1730 (2017-05-05)

The resting membrane potential (Δψ) of the cell is negative on the cytosolic side and determined primarily by the plasma membrane's selective permeability to K

Clofilium and other class III agents.

Steinberg, et al. et al.

Handbook of Experimental Pharmacology, 89, 389-389 (1989)

Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.

J P Arena et al.

Molecular pharmacology, 34(1), 60-66 (1988-07-01)

The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated guinea pig ventricular cells. Block of these channels by an externally applied quaternary nitrogen compound, clofilium, and two of its

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全球贸易项目编号

货号	GTIN
C2365-10MG	04061833475713
C2365-50MG	04061832897622

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