C2365
Clofilium tosylate
>97%, K+channel blocker, solid
别名:
4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate
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关于此项目
经验公式（希尔记法）:
C21H37ClN · C7H7O3S
化学文摘社编号:
分子量:
510.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Clofilium tosylate, >97%, solid
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc2ccc(Cl)cc2
InChI key
MOQZYUUHIWPDQC-UHFFFAOYSA-M
InChI
1S/C21H37ClN.C7H8O3S/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-6-2-4-7(5-3-6)11(8,9)10/h14-17H,4-13,18-19H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
assay
>97%
form
solid
color
white
solubility
H2O: soluble
Quality Level
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Biochem/physiol Actions
K+ channel blocker; cardiac depressant; anti-arrhythmic
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Wuyang Wang et al.
The Journal of cell biology, 216(6), 1715-1730 (2017-05-05)
The resting membrane potential (Δψ) of the cell is negative on the cytosolic side and determined primarily by the plasma membrane's selective permeability to K
Sean A Misek et al.
Molecular pharmacology, 101(1), 1-12 (2021-11-05)
Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal of this study was to use an unbiased computational
H Papp et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 67(5), 731-737 (2016-12-25)
Hyperventilation reduces partial pressure of CO
Clofilium and other class III agents.
Steinberg, et al. et al.
Handbook of Experimental Pharmacology, 89, 389-389 (1989)
W B Gough et al.
Cardiovascular research, 23(6), 554-559 (1989-06-01)
To determine whether ischaemic tissue is more sensitive than normal tissue to class III anti-arrhythmic agents, we studied the effects of the class III agents clofilium, d-sotalol and bretylium on normal and ischaemic Purkinje fibres one day after ligation of
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