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C2401

单响尾蛇毒蛋白

Name: 单响尾蛇毒蛋白
Brand: SIGMA

Pulmotoxic, powder

别名:

(-)-野百合碱, 野百合碱

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₃NO₆

化学文摘社编号:

315-22-0

分子量:

325.36

NACRES:

NA.77

PubChem Substance ID:

24892326

UNSPSC Code:

12352200

MDL number:

MFCD00084656

Beilstein/REAXYS Number:

48732

Form:

powder

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产品名称

单响尾蛇毒蛋白,

form

powder

mp

204 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

InChI key

QVCMHGGNRFRMAD-XFGHUUIASA-N

General description

野百合碱是属于吡咯烷嗪生物碱家族的大环化合物。这种成分在猪屎豆中天然存在。

Application

野百合碱已用于盐酸(HCl)注射液中，通过注入实验动物诱发肺动脉高压。

Biochem/physiol Actions

野百合碱可诱发大鼠肺血管综合征。这种成分具有公认毒性，可导致肝硬化、肝脏肿大、肝窦阻塞综合征和右心室肥大。野百合碱可抑制多种实验性肿瘤的生长.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

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Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Yunhong Zeng et al.

Aging, 13(14), 18238-18256 (2021-07-27)

N6-methyladenosine (m6A) modification is one of the most common chemical modifications of eukaryotic mRNAs, which play an important role in tumors and cardiovascular disease through regulating mRNA stability, splicing and translation. However, the changes of m6A mRNA and m6A-related enzymes

The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine

Gunaydin S, et al.

Cardiovascular Surgery (London, England), 10(2), 138-145 (2002)

Blockade of frontocortical-brain stem pathway prevents ventricular fibrillation of ischemic heart

Skinner JE and Reed JC

American Journal of Physiology. Heart and Circulatory Physiology, 240(2), H156-H163 (1981)

Bioinformatic analysis and validation of microRNA-508-3p as a protective predictor by targeting NR4A3/MEK axis in pulmonary arterial hypertension.

Yi Ma et al.

Journal of cellular and molecular medicine, 25(11), 5202-5219 (2021-05-05)

Pulmonary arterial hypertension (PAH) featured a debilitating progressive disorder. Here, we intend to determine diagnosis-valuable biomarkers for PAH and decode the fundamental mechanisms of the biological function of these markers. Two mRNA microarray profiles (GSE70456 and GSE117261) and two microRNA

The monocrotaline model of pulmonary hypertension in perspective.

Jose G Gomez-Arroyo et al.

American journal of physiology. Lung cellular and molecular physiology, 302(4), L363-L369 (2011-10-04)

Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure.

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全球贸易项目编号

货号	GTIN
C2401-1G	04061833475812
C2401-500MG	04061833475829

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