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Merck
CN

C2401

单响尾蛇毒蛋白

Pulmotoxic, powder

别名:

(-)-野百合碱, 野百合碱

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关于此项目

经验公式(希尔记法):
C16H23NO6
化学文摘社编号:
分子量:
325.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
48732
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产品名称

单响尾蛇毒蛋白,

InChI key

QVCMHGGNRFRMAD-XFGHUUIASA-N

SMILES string

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

form

powder

mp

204 °C (dec.) (lit.)

storage temp.

2-8°C

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Application

野百合碱已用于盐酸(HCl)注射液中,通过注入实验动物诱发肺动脉高压。

Biochem/physiol Actions

野百合碱可诱发大鼠肺血管综合征。这种成分具有公认毒性,可导致肝硬化、肝脏肿大、肝窦阻塞综合征和右心室肥大。野百合碱可抑制多种实验性肿瘤的生长.

General description

野百合碱是属于吡咯烷嗪生物碱家族的大环化合物。这种成分在猪屎豆中天然存在。

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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分析证书(COA)

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Superiority of desflurane over sevoflurane and isoflurane in the presence of pressure-overload right ventricle hypertrophy in rats
Blaudszun G and Morel DR
Anesthesiology, 117(5), 1051-1061 (2012)
Martin Connolly et al.
PloS one, 15(2), e0229409-e0229409 (2020-02-29)
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in pulmonary arterial hypertension are not known. Previous
Zhongkai Zhu et al.
Pulmonary circulation, 10(3), 2045894020922129-2045894020922129 (2020-09-15)
Pulmonary hypertension is a chronic vascular disease characterized by pulmonary vasoconstriction and pulmonary arterial remodeling. Pulmonary arterial remodeling is mainly due to small pulmonary arterial wall thickening and lumen occlusion. Previous studies have described intravascular changes in lung sections using
Yunhong Zeng et al.
Aging, 13(14), 18238-18256 (2021-07-27)
N6-methyladenosine (m6A) modification is one of the most common chemical modifications of eukaryotic mRNAs, which play an important role in tumors and cardiovascular disease through regulating mRNA stability, splicing and translation. However, the changes of m6A mRNA and m6A-related enzymes
The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
Gunaydin S, et al.
Cardiovascular Surgery (London, England), 10(2), 138-145 (2002)

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