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Merck
CN

C2517

氯氮卓 盐酸盐

别名:

7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride

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关于此项目

经验公式(希尔记法):
C16H14ClN3O · HCl
化学文摘社编号:
分子量:
336.22
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
207-117-8
MDL number:
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InChI key

DMLFJMQTNDSRFU-UHFFFAOYSA-N

InChI

1S/C16H14ClN3O.ClH/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15;/h2-9H,10H2,1H3,(H,18,19);1H

SMILES string

Cl[H].CNC1=Nc2ccc(Cl)cc2C(c3ccccc3)=[N+]([O-])C1

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

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Biochem/physiol Actions

The use of chlordiazepoxide during the first trimester might lead to congenital defects.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

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J K Pereira et al.
Life sciences, 65(10), PL101-PL107 (1999-09-28)
A single exposure to the elevated plus-maze test of anxiety reduces or abolishes the anxiolytic efficacy of benzodiazepines. The present study was designed to examine whether this phenomenon of "one-trial tolerance" resulted from a motivational deficit on trial 2. We
Psychologists' psychotropic drug reference. (1999)
D J Cash et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 704-711 (1997-11-14)
When rats were made tolerant to the benzodiazepine tranquilizer chlordiazepoxide (CDPX) by its steady administration, a particular gamma-aminobutyric acid type A (GABAA) receptor in cerebral cortex was modified. Its rate of desensitization in the absence of CDPX was enhanced (3-fold
A Agmo et al.
Neuropharmacology, 37(2), 223-232 (1998-07-29)
Previous studies have shown that the opiate antagonist naloxone blocks the anxiolytic-like effects of benzodiazepines in several models of anxiety, including the elevated plus-maze. Although naloxone preferentially binds to the mu opioid receptor, its selectivity is rather low. The opioid

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