C271
CX546
≥98% (HPLC), solid
别名:
1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
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About This Item
经验公式（希尔记法）:
C14H17NO3
CAS Number:
分子量:
247.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
white to off-white
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
O=C(N1CCCCC1)c2ccc3OCCOc3c2
InChI
1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
InChI key
LJUNPHMOGNFFOS-UHFFFAOYSA-N
基因信息
human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
一般描述
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
应用
CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
生化/生理作用
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
Positive AMPA glutamate receptor modulator.
免责声明
Photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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