biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human skeletal muscle, myocytes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... CCR1(1230)
mouse ... Ccr1(12768)
rat ... Ccr1(57301)
Immunogen
synthetic peptide corresponding to the third extracellular loop of human C-C chemokine receptor 1 (CCR-1), conjugated to KLH. The immunizing peptide has 80% homology with the rat gene and 85% homology with the mouse gene.
Biochem/physiol Actions
CCR1 is a seven transmembrane protein that binds to macrophage inflammatory protein 1 alpha (MIP-1 alpha), monocyte chemoattractant protein 3 (MCP-3) and myeloid progenitor inhibitory factor-1 (MPIF-1). It has important role in protecting the host from inflammatory responses, viruses and parasites.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
J Hesselgesser et al.
The Journal of biological chemistry, 273(25), 15687-15692 (1998-06-23)
The CC chemokines macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES (regulated on activation normal T cell expressed) have been implicated in rheumatoid arthritis and multiple sclerosis. Since their effects are mediated through the CCR1 chemokine receptor, we set up a small
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