C2755

Cortisone

Name: Cortisone
Brand: SIGMA

≥95%

别名:

17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa

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About This Item

经验公式（希尔记法）:

C₂₁H₂₈O₅

CAS Number:

53-06-5

分子量:

360.44

Beilstein:

1356062

EC 号:

200-162-4

MDL编号:

MFCD00003610

UNSPSC代码:

51111800

PubChem化学物质编号:

24278304

NACRES:

NA.77

主要文件

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生物来源

synthetic

质量水平

200

无菌性

non-sterile

方案

≥95%

表单

powder

技术

inhibition assay: suitable

mp

223-228 °C (dec.) (lit.)

溶解性

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES字符串

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

基因信息

human ... SERPINA6(866)

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应用

Cortisone has been used:

to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
in the determination of rates of cortisol oxidation by 11βHSD

生化/生理作用

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.