C2800
苯乙酸胆甾醇酯
≥98% (HPLC; detection at 258 nm)
别名:
3β-羟基-5-胆甾-3-苯乙酸酯, 5-胆甾烯-3β-ol 3-苯乙酸盐
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关于此项目
经验公式（希尔记法）:
C35H52O2
化学文摘社编号:
分子量:
504.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
EC Number:
251-781-1
MDL number:
产品名称
苯乙酸胆甾醇酯, ≥98% (HPLC; detection at 258 nm)
InChI key
JHFRODPXYCPTCM-ZTUKSAGPSA-N
InChI
1S/C35H52O2/c1-24(2)10-9-11-25(3)30-16-17-31-29-15-14-27-23-28(37-33(36)22-26-12-7-6-8-13-26)18-20-34(27,4)32(29)19-21-35(30,31)5/h6-8,12-14,24-25,28-32H,9-11,15-23H2,1-5H3/t25-,28?,29?,30?,31?,32?,34?,35?/m1/s1
SMILES string
O=C(O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)([H])[C@@]2(C)CC1)CC5=CC=CC=C5
biological source
synthetic (organic)
assay
≥98% (HPLC; detection at 258 nm)
form
crystalline powder
functional group
ester
shipped in
ambient
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
苯乙酸胆固醇酯是一种胆固醇酯，与低密度脂蛋白的中性核心有关。受体-LDL 复合物被溶酶体摄取并水解以从酯中释放胆固醇。酸性胆固醇酯水解酶负责胆固醇酯的水解；有缺陷的酶可导致人体动脉粥样硬化病变的形成。
Preparation Note
苯乙酸胆甾醇酯在氯仿中生成澄清无色溶液，浓度为 50 mg/mL。
flash_point_f
Not applicable
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Pieter H E Groot et al.
Journal of lipid research, 46(10), 2182-2191 (2005-07-19)
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions. Accordingly, LXR is considered an appealing drug target for
Shobha Ghosh et al.
Vascular pharmacology, 52(1-2), 1-10 (2009-11-03)
Accumulation of cholesteryl esters (CE) stored as cytoplasmic lipid droplets is the main characteristic of macrophage foam cells that are central to the development of atherosclerotic plaques. Since only unesterified or free cholesterol (FC) can be effluxed from the cells
Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.
M Krieger et al.
The Journal of biological chemistry, 253(12), 4093-4101 (1978-06-25)
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