C2832
胆固醇基 3β-N-氨基乙基氨基甲酸酯 盐酸盐
≥95%, Cholesterol derivative, powder
别名:
3β-[N-(二甲基氨基乙基)-氨基甲酰基]胆固醇, DC-Chol
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关于此项目
经验公式（希尔记法）:
C32H57ClN2O2
化学文摘社编号:
分子量:
537.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
胆固醇基 3β-N-氨基乙基氨基甲酸酯 盐酸盐, ≥95%
SMILES string
Cl[H].[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)NCCN(C)C)[C@H](C)CCCC(C)C
InChI key
ISXSJGHXHUZXNF-LXZPIJOJSA-N
InChI
1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H/t23-,25+,26+,27-,28+,29+,31+,32-;/m1./s1
assay
≥95%
form
powder
storage temp.
−20°C
Quality Level
相关类别
Application
胆固醇3β-N-(二甲基氨基乙基)氨基甲酸酯盐酸盐已被用作双层膜稳定剂 以及用于核酸转移。
这种阳离子胆固醇衍生物与二油酰基L-α-磷脂酰乙醇胺形成脂质体，用于高效转染哺乳动物细胞系。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Gene Targeting Protocols (2000)
M J Campbell
BioTechniques, 18(6), 1027-1032 (1995-06-01)
Cationic liposomes are being utilized for the delivery of DNA into mammalian cells both in vitro and in vivo. In this report, we describe a rapid, simple injection method for the preparation of cationic liposomes that requires no special equipment.
S Szala et al.
Gene therapy, 3(11), 1026-1031 (1996-11-01)
An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and DOPE is dioleoylphosphatidylethanolamine) for transfer of Escherichia coli cytosine deaminase 'suicide' gene under the control
P S Ajmani et al.
Neurochemical research, 24(5), 699-703 (1999-05-27)
Cationic lipid formulations consisting of 3beta [N-(N', N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the helper lipid dioleoylphosphatidylethanolamine (DOPE) (1.5: 1 molar ratio) were prepared by solvent evaporation and sized by high pressure extrusion. Liposomes made of 1:1 molar ratio 1 ,2-dioleoyl-3-trimethyl-ammonium-propane (DOTAP)/DOPE
N J Caplen et al.
Gene therapy, 2(9), 603-613 (1995-11-01)
Clinical trials using cationic liposome-mediated DNA transfer have now been initiated for several disorders including cystic fibrosis. Previous studies have shown that the level of gene expression achieved may be dependent on the formulation of the DNA-liposome complex and the
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