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C2901

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated

Name: Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated
Brand: SIGMA

≥95% (HPLC), powder

别名:

CCK-8, non-sulfated

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关于此项目

经验公式（希尔记法）:

C₄₉H₆₂N₁₀O₁₃S₂

化学文摘社编号:

25679-24-7

分子量:

1063.21

NACRES:

NA.32

PubChem Substance ID:

24892546

UNSPSC Code:

12352202

MDL number:

MFCD00076488

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

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Quality Level

200

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P06307

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(Cc4ccccc4)C(N)=O

InChI

1S/C49H62N10O13S2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65)

InChI key

OIXQINQYMGNCII-UHFFFAOYSA-N

Gene Information

human ... CCK(885)

Application

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated has been used in the specificity testing against gastrin and pepsinogen I proteins.

Biochem/physiol Actions

Cholecystokinin (CCK) is a 115 amino acid preprohormone and a neurotransmitter. It exists in many isoforms. The octapeptide of CCK (CCK-8S) is the most abundant form. CCK is mapped to human chromosome 3p22.1. CCK interacts with receptors of the gastrointestinal tract and nervous system. Polymorphisms in the CCK is implicated in hallucinations in patients with Parkinson′s disease. CCK plays a key role in the activation of the calcineurin-regulated nuclear factor of activated T-cells (NFATs).

Biologically inactive form of CCK-8; CCK_B/gastrin receptor agonist that has no activity at the CCK_A receptor.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000524135

0000514341

0000260807

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Genetic substrates of psychosis in patients with Parkinson's disease: a critical review.

Lenka A, et al.

Journal of the Neurological Sciences, 364(5), 33-41 (2016)

Advances in molecular genetics of panic disorder.

Maron E, et al.

Molecular Psychiatry, 15(7), 681-681 (2010)

Atrophic gastritis serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study.

Sipponen P, et al.

Scandinavian Journal of Gastroenterology, 37(7), 785-791 (2002)

IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis.

Franziska G Thiel et al.

Scientific reports, 13(1), 10833-10833 (2023-07-05)

Acute pancreatitis (AP), which is characterized by self-digestion of the pancreas by its own prematurely activated digestive proteases, is a major reason for hospitalization. The autodigestive process causes necrotic cell death of pancreatic acinar cells and the release of damage

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.

Gales C, et al.

Molecular Pharmacology, 63(5), 973-982 (2003)

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全球贸易项目编号

货号	GTIN
C2901-1MG	04061833484838

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