C2970
Monoclonal Anti-Cathepsin L antibody produced in mouse
clone 33/2, ascites fluid
别名:
Anti-CATL, Anti-CTSL, Anti-MEP
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Conjugate:
unconjugated
Clone:
33/2, monoclonal
Application:
immunohistochemistry (frozen sections)
indirect ELISA
microarray
western blot
indirect ELISA
microarray
western blot
Species reactivity:
mouse, mink, human, rat
Citations:
10
Technique(s):
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line
Uniprot accession no.:
产品名称
Monoclonal Anti-Cathepsin L antibody produced in mouse, clone 33/2, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
33/2, monoclonal
mol wt
antigen (human cathepsin L) 25 kDa
antigen (human procathepsin L) 42 kDa
contains
15 mM sodium azide
species reactivity
mouse, mink, human, rat
technique(s)
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CTSL1(1514)
mouse ... Ctsl(13039)
rat ... Ctsl1(25697)
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Biochem/physiol Actions
Cathepsin L expression is correlated with the metastatic potential of transformed cells. Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.
Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form. It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.
Immunogen
procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
Goulet B, et al.
Molecular Cancer Research, 5(9), 899-907 (2007)
Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) virulence propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
Collins PR, et al.
Test, 279(17), 17038-17046 (2004)
Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number
Lombardi G, et al.
Journal of Immunology, 174(11), 7022-7032 (2005)
Cysteine cathepsins: from structure, function and regulation to new frontiers
Turk V, et al
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1824(1), 68-88 (2012)
Kazuyoshi Yanagihara et al.
Cancer science, 96(6), 323-332 (2005-06-17)
The number of published studies on peritoneal dissemination of scirrhous gastric carcinoma is very small as a result of the unavailability of highly reproducible animal models. Orthotopic implantation of HSC-44PE and HSC-58 (scirrhous gastric carcinoma-derived cell lines) cells into nude
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