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Merck
CN

C3021

双氰异烟胺

≥93%

别名:

Cobinamide dicyanide, 因子 B, 苯钴胺

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关于此项目

经验公式（希尔记法）:
C50H72CoN13O8
化学文摘社编号:
27792-36-5
分子量:
1042.12
NACRES:
NA.79
PubChem Substance ID:
24892558
UNSPSC Code:
12352205
MDL number:
MFCD00056330

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产品名称

双氰异烟胺, ≥93%

InChI

1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,59-60H,10-18,20-22H2,1-9H3,(H2,49,61)(H2,50,62)(H2,51,63)(H2,52,64)(H2,53,65)(H2,54,66)(H,55,67);;;/b30-19-,39-24-,40-25-;;;/t23-,26+,27+,28+,29-,43?,45+,46-,47-,48-;;;/m0.../s1

SMILES string

N#C[Co]C#N.C[C@H](O)CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O

InChI key

NJATWHPHZUGTHR-GXEWULDJSA-N

biological source

synthetic (organic)

assay

≥93%

form

powder

impurities

≤0.1% vitamin B12

color

purple to very dark purple

storage temp.

−20°C

Quality Level

200

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相关类别

Application

二氰基钴啉醇酰胺已被用于维生素B12结合蛋白（BtuF）的结晶。它还被用于BtuCD-BtuF相互作用的脱稳。
用于测定内因子制剂中的非内因子（R蛋白）。

Biochem/physiol Actions

二氰基钴啉醇酰胺（Cbi）可用作可溶性鸟苷酸环化酶（sGC）辅助激活因子，并以N末端调节区为靶点。该作用类似于佛司可林对腺苷酸环化酶的作用。二氰基钴啉醇酰胺可提高大鼠细胞内环单磷酸鸟苷（cGMP）的水平，并在大鼠中表现出血管舒张活性。它可与多种钴胺素一起用于HIV-1整合酶和一氧化氮合酶抑制的研究。

General description

二氰基钴啉醇酰胺也称为因子b，是辅酶B12的前体。它具有咕啉环结构，钴（Co）原子的六个配位点中有四个是吡咯氮原子。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000446682
0000446682
0000483620
0000483620
0000509050

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