C3025
(±)-氯苯那敏 马来酸盐
≥99% (perchloric acid titration)
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关于此项目
经验公式（希尔记法）:
C16H19ClN2 · C4H4O4
化学文摘社编号:
分子量:
390.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
204-037-5
MDL number:
产品名称
(±)-氯苯那敏 马来酸盐, ≥99% (perchloric acid titration)
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
assay
≥99% (perchloric acid titration)
form
powder
mp
130-135 °C (lit.)
originator
Bayer
Quality Level
Gene Information
human ... HRH1(3269)
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Application
(±)-马来酸氯苯吡胺已被用于：
- 作为H1受受体拮抗剂用于测定受体功能
- 阻断化合物48/80对血浆IGF-I的作用
- 作为标准品通过配有电位差计的顺序进样器用于快速感应和测定
Biochem/physiol Actions
H 1 组胺受体拮抗剂。
马来酸氯苯吡胺（CPM）可预防鼻炎和荨麻疹。它常用于治疗多种过敏症状。这种抗组胺药也用于小动物的兽医治疗。
General description
马来酸氯苯吡胺（CPM）/（3-（4-氯苯基）-N，N-二甲基-3-吡啶-2-基-丙烷-1-胺是一种烷基胺抗组胺药。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat
Liao W, et al.
European Journal of Pharmacology, 374(3), 471-476 (1999)
Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer
Saleh TA
Journal of Pharmaceutical Analysis, 1(4), 246-250 (2011)
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord
Zhang L, et al.
Molecular Brain, 7(1), 25-25 (2014)
V Alagarsamy et al.
European journal of medicinal chemistry, 43(11), 2331-2337 (2007-11-23)
A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. The starting material 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one was synthesized from 2-methyl aniline by a novel innovative route. The title compounds were tested for their in vivo
Functionalized Fe3O4 Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl
Moustafa AA, et al.
Journal of Analytical Methods in Chemistry (2019)
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