Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Lyophilized from 0.1% TFA in H2O