主要文件

查看所有文档

C3042

Corticotropin Releasing Factor human, rat

Name: Corticotropin Releasing Factor human, rat
Brand: SIGMA

≥95% (HPLC), powder

别名:

CRF, CRH

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₀₈H₃₄₄N₆₀O₆₃S₂

化学文摘社编号:

86784-80-7

分子量:

4757.45

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00213806

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

Quality Level

200

biological source

human, rat

assay

≥95% (HPLC)

form

powder

mol wt

4757.45

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, colorless

UniProt accession no.

P06850

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:

as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Other Notes

Lyophilized from 0.1% TFA in H2O

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation

Simard M, et al.

Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)

On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders.

A Slominski

The British journal of dermatology, 160(2), 229-232 (2009-02-04)

Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes

Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone

Thome UH, et al.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(2), L376-L385 (2003)

Salt appetite

Vitamins & Hormones (2017)

Transcriptional regulation of hypothalamic corticotropin-releasing factor gene

Vitamins & Hormones, 82, 301-317 (2010)

查看所有相关文献

全球贸易项目编号

货号	GTIN
C3042-.1MG	04061833485231
C3042-.5MG	04061832676371
C3042-250UG	04061832676388

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持