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C3138

组织蛋白酶D 来源于牛脾脏

Name: 组织蛋白酶D 来源于牛脾脏
Brand: SIGMA

lyophilized powder, ≥2.0 units/mg protein

别名:

CTSD

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关于此项目

化学文摘社编号:

9025-26-7

UNSPSC Code:

12352204

NACRES:

NA.32

EC 号:

3.4.23.5 (BRENDA, IUBMB)

MDL number:

MFCD00130749

Specific activity:

≥2.0 units/mg protein

Assay:

10—70% protein (biuret)

Biological source:

bovine spleen

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biological source

bovine spleen

Quality Level

200

assay

10—70% protein (biuret)

form

lyophilized powder

specific activity

≥2.0 units/mg protein

mol wt

~45 kDa

manufacturer/tradename

Sigma-Aldrich

technique(s)

activity assay: suitable

color

dark brown

suitability

suitable for molecular biology

UniProt accession no.

P80209

application(s)

life science and biopharma

storage temp.

−20°C

Gene Information

cow ... CTSD(282883)

General description

研究领域：细胞信号传导

组织蛋白酶D是可溶性内涵体-溶酶体天冬氨酸蛋白酶，在粗面内质网中以前体酶原(preprocathepsin D)形式合成。由11p15.5区的CTSD基因编码。

Application

组织蛋白酶D（来自牛脾）已用于：

体外剂量依赖性荧光活性检测。
消化体外髓鞘少突胶质细胞糖蛋白(MOG)，以研究丙二醛(MDA)修饰MOG的摄取及其对中枢神经系统自身免疫的意义。
酶促消化关节软骨的蛋白聚糖部分，以测定两种不同组织结构水平下的软骨弹性模量。
组织蛋白酶D活性检测。

Biochem/physiol Actions

核内体-溶酶体天冬氨酸蛋白酶，与乳腺癌转移和阿尔茨海默病有关。人们发现，在凋亡的人包皮成纤维细胞中，溶酶体释放组织蛋白酶D先于释放细胞色素c和膜电位丧失。

组织蛋白酶D是一种核内体-溶酶体天冬氨酸蛋白酶，与乳腺癌转移和阿尔茨海默病有关。人们发现，在凋亡的人包皮成纤维细胞中，溶酶体释放组织蛋白酶D先于释放细胞色素c和膜电位丧失。诱导凋亡后12至24小时，PC12细胞中的组织蛋白酶D水平升高。

Physical form

含有柠檬酸盐缓冲液盐的冻干粉

Other Notes

在pH 3.0、37 °C条件下，一个单位可在一分钟内使一毫升溶液的A₂₈₀增加1.0（以血红蛋白为底物，对TCA可溶性产物进行测定（1 cm光程））。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料

动植物源性产品

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历史批次信息供参考:

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Dynamic elastic modulus of porcine articular cartilage determined at two different levels of tissue organization by indentation-type atomic force microscopy.

Martin Stolz et al.

Biophysical journal, 86(5), 3269-3283 (2004-04-28)

Cartilage stiffness was measured ex vivo at the micrometer and nanometer scales to explore structure-mechanical property relationships at smaller scales than has been done previously. A method was developed to measure the dynamic elastic modulus, |E(*)|, in compression by indentation-type

Cathepsin D-Managing the Delicate Balance.

Olja Mijanovic et al.

Pharmaceutics, 13(6) (2021-07-03)

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute

Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: a potential target for cancer therapy.

Marie Maynadier et al.

Journal of controlled release : official journal of the Controlled Release Society, 171(2), 251-257 (2013-08-01)

Implication of the intracellular proteolytic activity of Cathepsin D (CathD), a lysosomal aspartyl-protease overexpressed in numerous solid tumors, has been evidenced on tumor growth. Its intracellular inhibition by potent inhibitors such as pepstatin constitutes a relevant but challenging molecular target.

ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.

Yoko Shiba et al.

Current biology : CB, 23(19), 1945-1951 (2013-10-01)

ArfGAPs are known to be involved in cargo sorting in COPI transport. However, the role of ArfGAPs in post-Golgi membrane traffic has not been defined. To determine the function of ArfGAPs in post-Golgi traffic, we used small interfering RNA to

Cathepsin D from porcine and bovine spleen.

T Takahashi et al.

Methods in enzymology, 80 Pt C, 565-581 (1981-01-01)

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全球贸易项目编号

货号	GTIN
C3138-10UN	04061833492437
C3138-40UN	04061832777054
C3138-5UN	04061833485408
C3138-20UN	04061833492444

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