C3411
2′,7′-双(2-羧乙基)-5(6)-羧基荧光素
≥90% (HPLC), Fluorescent indicator, powder
别名:
BCECF
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关于此项目
经验公式（希尔记法）:
C27H20O11
化学文摘社编号:
分子量:
520.44
Beilstein:
8375770
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
产品名称
2′,7′-双(2-羧乙基)-5(6)-羧基荧光素, ≥90% (HPLC)
质量水平
方案
≥90% (HPLC)
表单
powder
储存温度
−20°C
SMILES字符串
OC(=O)CCc1cc2c(OC3=CC(=O)C(CCC(O)=O)=CC3=C2c4cc(ccc4C(O)=O)C(O)=O)cc1O
InChI
1S/C27H20O11/c28-19-10-21-17(7-12(19)2-5-23(30)31)25(16-9-14(26(34)35)1-4-15(16)27(36)37)18-8-13(3-6-24(32)33)20(29)11-22(18)38-21/h1,4,7-11,28H,2-3,5-6H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)
InChI key
DKROGDOAOXDINY-UHFFFAOYSA-N
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相关类别
应用
2′,7′-双(2-羧乙基)-5(6)-羧基荧光素已被用于荧光筛选测定中，以确定pH。
生化/生理作用
2′,7′-双(2-羧乙基)-5(6)-羧基荧光素(BCECF) 可用于研究多药耐药相关蛋白（MRP）转运蛋白在细胞内的作用。已知BCECF会干扰药物外排相互作用。
用于测量淋巴细胞中细胞质pH值的荧光指示剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Biochemical and biophysical research communications, 517(1), 140-145 (2019-07-20)
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Heux S, et al.
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Long non-coding RNAs (lncRNAs) have been shown to regulate numerous processes in the human genome, but the function of these transcripts in vascular aging is largely unknown. We aim to characterize the expression of lncRNAs in endothelial aging and analyse
Corbin J Bachmeier et al.
Journal of pharmaceutical sciences, 93(4), 932-942 (2004-03-05)
2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) is a fluorescent probe used to examine multidrug resistance-associated protein (MRP) transporter activity in cells. BCECF is introduced into the cell as the nonfluorescent membrane permeable acetoxymethyl ester, BCECF-AM, where it is hydrolyzed to the membrane impermeable BCECF.
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