C3595
Anti-Connexin-32 (106-124) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-CMTX, Anti-CMTX1, Anti-CX32
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (f), WB
Citations:
9
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 27 kDa
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry (frozen sections): 1:400 using frozen rat liver sections, western blot: 1:400 using a rat liver membrane preparation
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GJB1(2705)
mouse ... Gjb1(14618)
rat ... Gjb1(29584)
General description
Connexins (Cx) are a multi-gene family of highly related proteins with molecular weights ranging from 26 to 70 kDa. The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops, and a C-terminal cytoplasmic tail of varying length. The 27kD connexin protein (connexin 32, Cx32) is expressed in several tissues.
Immunogen
synthetic human connexin-32 peptide (amino acids 106-124).
Application
Anti-Connexin 32 (265-279) antibody produced in rabbit is suitable for immunohistochemistry (frozen sections) at a dilution of 1:400 using frozen rat liver tissue. It is also suitable for western blot at a dilution of 1:400 using a rat liver membrane preparation.
Anti-Connexin-32 (106-124) antibody produced in rabbit has been used in:
- western blotting
- immunofluorescence
- immunohistology
Biochem/physiol Actions
Cx32 mutations is associated with X-linked Charcot-Marie-Tooth (CMTX) disease, which leads to myelin disruption and axonal degeneration.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro
Koenig S, et al.
Journal of Hepatology, 44(6), 1115-1124 (2006)
Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection
Rodriguez-Sinovas A, et al.
The Journal of Physiology, 588(7), 1139-1151 (2010)
Silvia Ravera et al.
Molecular neurobiology, 53(4), 2468-2479 (2015-06-03)
Recently, we have demonstrated that myelin conducts an extramitochondrial oxidative phosphorylation, hypothesizing a novel supportive role for myelin in favor of the axon. We have also hypothesized that the ATP produced in myelin could be transferred thought gap junctions. In
Diego López et al.
Experimental physiology, 94(10), 1088-1097 (2009-07-21)
Previous studies demonstrated that intercellular communication through endothelial, smooth muscle or myoendothelial connexin channels contributes to the control of vascular tone. At least four connexin types are present in the arterial wall. The aim of the present work was to
Transient, recurrent, white matter lesions in X-linked Charcot-Marie-Tooth disease with novel connexin 32 mutation
Hanemann CO, et al.
Archives of Neurology, 60(4), 605-609 (2003)
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