C3635
4-氯-DL-苯基丙氨酸甲酯 盐酸盐
Tryptophan hydroxylase inhibitor, powder
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线性分子式:
ClC6H4CH2CH(NH2)CO2CH3·HCl
化学文摘社编号:
分子量:
250.12
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
产品名称
4-氯-DL-苯基丙氨酸甲酯 盐酸盐,
表单
powder
质量水平
mp
186-189 °C (lit.)
储存温度
−20°C
SMILES字符串
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
基因信息
human ... TPH1(7166), TPH2(121278)
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一般描述
4-氯-DL-苯丙氨酸甲酯盐酸盐刺激妊娠小鼠的葡萄糖耐受不良。研究表明4-氯-DL-苯丙氨酸甲酯盐酸盐与啮齿动物的认知缺陷有关。
应用
4-氯- DL -苯丙氨酸甲酯盐酸盐已用于诱导大鼠 5-羟色胺 (5-HT) 耗竭。
生化/生理作用
色氨酸羟化酶抑制剂。
色氨酸羟化酶抑制剂。比对氯苯基丙氨酸更易穿越血脑屏障。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Jessica E Monk et al.
Frontiers in behavioral neuroscience, 12, 246-246 (2018-11-09)
Negative affective states such as anxiety and depression pose a risk to animal welfare, however, practical tests for assessing these states in animals are limited. In humans, anxious individuals are shown to pay more attention toward threatening information than non-anxious
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
du Jardin KG, et al.
European Neuropsychopharmacology, 24(1), 160-171 (2014)
Janel M Boyce-Rustay et al.
Neuropharmacology, 55(5), 803-811 (2008-07-16)
Ethanol exerts effects on the brain noradrenergic system, and these are thought to contribute to the sedative/hypnotic (depressant) effects of ethanol. Recent studies suggest that the norepinephrine transporter (NET) plays an important role in modulating ethanol's depressant effects. The aim
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