C3635
4-氯-DL-苯基丙氨酸甲酯 盐酸盐
Tryptophan hydroxylase inhibitor, powder
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线性分子式:
ClC6H4CH2CH(NH2)CO2CH3·HCl
化学文摘社编号:
分子量:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
238-024-0
MDL number:
产品名称
4-氯-DL-苯基丙氨酸甲酯 盐酸盐,
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
SMILES string
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
form
powder
mp
186-189 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
human ... TPH1(7166), TPH2(121278)
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General description
4-氯-DL-苯丙氨酸甲酯盐酸盐刺激妊娠小鼠的葡萄糖耐受不良。研究表明4-氯-DL-苯丙氨酸甲酯盐酸盐与啮齿动物的认知缺陷有关。
Application
4-氯- DL -苯丙氨酸甲酯盐酸盐已用于诱导大鼠 5-羟色胺 (5-HT) 耗竭。
Biochem/physiol Actions
色氨酸羟化酶抑制剂。
色氨酸羟化酶抑制剂。比对氯苯基丙氨酸更易穿越血脑屏障。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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du Jardin KG, et al.
European Neuropsychopharmacology, 24(1), 160-171 (2014)
Jessica E Monk et al.
Frontiers in behavioral neuroscience, 12, 246-246 (2018-11-09)
Negative affective states such as anxiety and depression pose a risk to animal welfare, however, practical tests for assessing these states in animals are limited. In humans, anxious individuals are shown to pay more attention toward threatening information than non-anxious
Irina B Deryabina et al.
International journal of molecular sciences, 21(6) (2020-03-22)
The processes of memory formation and its storage are extremely dynamic. Therefore, the determination of the nature and temporal evolution of the changes that underlie the molecular mechanisms of retrieval and cause reconsolidation of memory is the key to understanding
Pascal Branchereau et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(7), 2598-2606 (2002-03-30)
Spontaneous synchronous rhythmic activities are a common feature of immature neuronal networks. Although the mechanisms underlying such activities have been studied extensively, whether they might be controlled by modulatory information remains questionable. Here, we investigated the role of descending serotonergic
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
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