C3635
4-氯-DL-苯基丙氨酸甲酯 盐酸盐
Tryptophan hydroxylase inhibitor, powder
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关于此项目
线性分子式:
ClC6H4CH2CH(NH2)CO2CH3·HCl
化学文摘社编号:
分子量:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
238-024-0
MDL number:
产品名称
4-氯-DL-苯基丙氨酸甲酯 盐酸盐,
form
powder
Quality Level
mp
186-189 °C (lit.)
storage temp.
−20°C
SMILES string
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChI key
GCBCWTWQAFLKJG-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
4-氯-DL-苯丙氨酸甲酯盐酸盐刺激妊娠小鼠的葡萄糖耐受不良。研究表明4-氯-DL-苯丙氨酸甲酯盐酸盐与啮齿动物的认知缺陷有关。
Application
4-氯- DL -苯丙氨酸甲酯盐酸盐已用于诱导大鼠 5-羟色胺 (5-HT) 耗竭。
Biochem/physiol Actions
色氨酸羟化酶抑制剂。比对氯苯基丙氨酸更易穿越血脑屏障。
色氨酸羟化酶抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
du Jardin KG, et al.
European Neuropsychopharmacology, 24(1), 160-171 (2014)
Irina B Deryabina et al.
International journal of molecular sciences, 21(6) (2020-03-22)
The processes of memory formation and its storage are extremely dynamic. Therefore, the determination of the nature and temporal evolution of the changes that underlie the molecular mechanisms of retrieval and cause reconsolidation of memory is the key to understanding
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C3635-25G | 04061833618660 |
| C3635-1G | 04061826690192 |
| C3635-5G | 04061833427637 |