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C3647

Z-L-Lys-SBzl hydrochloride

Name: Z-<SC>L</SC>-Lys-SBzl hydrochloride
Brand: SIGMA

≥98% (TLC), suitable for ligand binding assays

别名:

N-α-Cbz-L-lysine thiobenzyl ester hydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₆N₂O₃S · HCl

化学文摘社编号:

69861-89-8

分子量:

422.97

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24892633

NACRES:

NA.26

MDL number:

MFCD00058089

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产品名称

Z-L-Lys-SBzl hydrochloride,

assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

Cl.NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)SCc2ccccc2

InChI

1S/C21H26N2O3S.ClH/c22-14-8-7-13-19(20(24)27-16-18-11-5-2-6-12-18)23-21(25)26-15-17-9-3-1-4-10-17;/h1-6,9-12,19H,7-8,13-16,22H2,(H,23,25);1H/t19-;/m0./s1

InChI key

PNDSXGXPDJRQAV-FYZYNONXSA-N

Application

Z-L-Lys-SBzl hydrochloride has been used as a thioesther substrate in photometric assay and as substrate in determining mast cell protease enzyme activity.

Biochem/physiol Actions

N-α-Cbz-L-lysine thiobenzyl ester (Z-L-Lys-SBzl) is used to identify and characterize specific protease/esterase/granzyme activities associated with lymphocyte cytoplasmic granules.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The isolation and purification of a dual specific mast cell-derived protease from parasitised caprine jejunal tissue

Macaldowie CN, et al.

Research in Veterinary Science, 64(1), 17-24 (1998)

The major component of Na-CBZ-L-lysine thiobenzyl ester (BLT)-specific proteases in cytoplasmic granules of murine intraepithelial lymphocytes is granzyme A.

Kato Y, Yokochi T, Sasaki K, et al.

Immunobiol., 196, 465-474 (1997)

2-chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor.

B A Williams et al.

Experimental cell research, 233(1), 187-197 (1997-05-25)

The effect of 2-chloroadenosine (2CA), an adenosine receptor agonist, on the activation status of mouse natural killer (NK) cells was determined. Splenic lymphocytes incubated with 2CA exocytosed an NK cell-associated granzyme with N alpha-CBZ-L-lysine thiobenzyl ester (BLT) esterase activity in

Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.

Andrea Kocsis et al.

Journal of immunology (Baltimore, Md. : 1950), 185(7), 4169-4178 (2010-09-08)

The complement system, an essential part of the innate immune system, can be activated through three distinct routes: the classical, the alternative, and the lectin pathways. The contribution of individual activation pathways to different biological processes can be assessed by

Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.

Gregory D Rak et al.

PLoS biology, 9(9), e1001151-e1001151 (2011-09-21)

Accumulation of filamentous actin (F-actin) at the immunological synapse (IS) is a prerequisite for the cytotoxic function of natural killer (NK) cells. Subsequent to reorganization of the actin network, lytic granules polarize to the IS where their contents are secreted

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全球贸易项目编号

货号	GTIN
C3647-100MG	04061832415925
C3647-25MG	04061832415932

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