C3735
细胞色素P450 人
1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
生物来源
human
质量水平
重组
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
表单
solution
比活
≥4 units/pmol enzyme
分子量
45-60 kDa
包装
vial of 0.5 nmol
技术
activity assay: suitable
溶解性
water: soluble
适用性
suitable for molecular biology
UniProt登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... CYP1A1(1543)
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一般描述
研究领域：免疫和CKS
细胞色素P450(CYP)酶系是由P450基因编码的一系列酶。这类酶是膜结合的血红素蛋白。主要存在于肝脏内质网中。’
细胞色素P450(CYP)酶系是由P450基因编码的一系列酶。这类酶是膜结合的血红素蛋白。主要存在于肝脏内质网中。’
生化/生理作用
细胞色素P450是异质性同工酶家族，其主要功能是氧化小分子，发挥中间代谢（如脂肪酸）功能和对外源性化合物（药物或毒素）进行解毒。有些同工型具有有限的底物特异性，而其他同工酶则比较混杂。CYP1A1亚型催化乙氧基试卤灵的7-脱乙基。细胞色素P450(CYP)在外源物解毒、细胞代谢和稳态中起重要作用。药物相互作用的一种主要机制就是激活或抑制这类酶。CYP酶可被多种外源物和内源底物经由受体依赖途径转录激活。基于代谢的药物相互作用主要影响就是抑制这类酶，许多化疗药物可通过抑制或诱导细胞色素P450酶系引发药物互作。
外形
100 mM 磷酸钾缓冲液，pH 7.4溶液。
制备说明
含人CYP1A1和重组人NADPH-P450还原酶的微粒体。
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Palrasu Manikandan et al.
Current drug targets, 19(1), 38-54 (2017-01-27)
The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions. CYP enzymes can be
Tomas Erban et al.
Biomedical chromatography : BMC, 26(9), 1062-1065 (2011-11-29)
A 96-well microplate-based HPLC endpoint assay is described for the determination of NADPH-cytochrome P450 reductase (CPR) activity. Novel sampling of NADPH into microplates was optimized. Separation was performed on a Zorbax Eclipse XDB-C₁₈ analytical 4.6 × 150 mm, 5 µm column. To validate the
Moritz Walter et al.
Toxicology in vitro : an international journal published in association with BIBRA, 59, 215-220 (2019-04-21)
Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate
D P Bofinger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 62(2), 299-314 (2001-07-14)
Endometriosis is a debilitating disease estimated to affect 10% of reproductive-age women and characterized by the growth of endometrial tissue outside of the uterus. The present study characterizes a human endometrial explant culture model for studying the direct effects of
David Stucki et al.
Archives of biochemistry and biophysics, 687, 108383-108383 (2020-04-27)
Intracellular carbon monoxide (CO) is a gaseous signaling molecule and is generated enzymatically by heme oxygenases upon degradation of heme to billiverdin. Target structures for intracellular produced CO are heme proteins including cytochrome c oxidase of the respiratory chain, cytochrome
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