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Merck
CN

C3909

Sigma-Aldrich

D-环丝氨酸

synthetic

别名:

(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮

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关于此项目

经验公式(希尔记法):
C3H6N2O2
化学文摘社编号:
分子量:
102.09
Beilstein:
80798
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.28
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生物来源

synthetic

质量水平

表单

powder

mp

147 °C (dec.) (lit.)

溶解性

water: 50 mg/mL, clear, colorless to light yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用机制

cell wall synthesis | interferes

储存温度

−20°C

SMILES字符串

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI key

DYDCUQKUCUHJBH-UWTATZPHSA-N

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一般描述

Chemical structure: amino acid derivatives

应用

D-cycloserine has been used to inhibit serine hydroxymethyltransferase.

生化/生理作用

作用方式:抑制细胞壁生物合成(D-Ala 肽键形成)。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Michael Davis et al.
Biological psychiatry, 60(4), 369-375 (2006-08-22)
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with behavior therapy for the treatment of many anxiety disorders has generally lead to only modest gains. In this article we suggest that pharmacotherapy aimed not at treating the symptoms of
Ram Maharjan et al.
Molecular biology and evolution, 32(2), 380-391 (2014-11-13)
Evolutionary innovations are dependent on mutations. Mutation rates are increased by adverse conditions in the laboratory, but there is no evidence that stressful environments that do not directly impact on DNA leave a mutational imprint on extant genomes. Mutational spectra
Karyn M Myers et al.
Biological psychiatry, 71(11), 947-955 (2012-05-15)
D-cycloserine (DCS) is an N-methyl-D-aspartate (NMDA) receptor partial agonist that facilitates extinction of conditioned fear in animals and cue exposure therapy (CET) for fear and anxiety disorders in people. Recent preclinical and clinical studies have examined the effect of DCS
Stefan G Hofmann et al.
CNS drug reviews, 12(3-4), 208-217 (2007-01-18)
Anxiety disorders are among the most common mental disorders. One of the most effective strategies to treat anxiety disorders is exposure therapy with or without cognitive intervention. Fear reduction in exposure therapy is similar to extinction learning. Preclinical studies suggest

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