C3909
D-环丝氨酸
synthetic
别名:
(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮
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关于此项目
经验公式（希尔记法）:
C3H6N2O2
化学文摘社编号:
分子量:
102.09
Beilstein:
80798
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.28
生物来源
synthetic
质量水平
表单
powder
mp
147 °C (dec.) (lit.)
溶解性
water: 50 mg/mL, clear, colorless to light yellow
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
作用机制
cell wall synthesis | interferes
储存温度
−20°C
SMILES字符串
N[C@@H]1CONC1=O
InChI
1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
InChI key
DYDCUQKUCUHJBH-UWTATZPHSA-N
基因信息
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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一般描述
Chemical structure: amino acid derivatives
应用
D-cycloserine has been used to inhibit serine hydroxymethyltransferase.
生化/生理作用
作用方式：抑制细胞壁生物合成（D-Ala 肽键形成）。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。
其他说明
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Karyn M Myers et al.
Biological psychiatry, 71(11), 947-955 (2012-05-15)
D-cycloserine (DCS) is an N-methyl-D-aspartate (NMDA) receptor partial agonist that facilitates extinction of conditioned fear in animals and cue exposure therapy (CET) for fear and anxiety disorders in people. Recent preclinical and clinical studies have examined the effect of DCS
Marta Portero-Tresserra et al.
Neurobiology of learning and memory, 100, 1-11 (2012-12-04)
It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or
Michael Davis et al.
Biological psychiatry, 60(4), 369-375 (2006-08-22)
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with behavior therapy for the treatment of many anxiety disorders has generally lead to only modest gains. In this article we suggest that pharmacotherapy aimed not at treating the symptoms of
Bram Vervliet
Acta psychologica, 127(3), 601-613 (2007-08-21)
This review addresses the effects of the cognitive enhancer D-cycloserine (DCS) on the memory processes that occur in conditioned fear extinction, which is the experimental model for exposure techniques to reduce clinical anxiety. All reported rat studies show an enhanced
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