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安全信息

C3909

Sigma-Aldrich

D-环丝氨酸

synthetic

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别名:
(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮
经验公式（希尔记法）:
C3H6N2O2
CAS号:
68-41-7
分子量:
102.09
Beilstein:
80798
EC 号:
200-688-4
MDL编号:
MFCD00005353
PubChem化学物质编号:
24277962

生物来源

synthetic

形式

powder

mp

147 °C (dec.) (lit.)

溶解性

water: 50 mg/mL, clear, colorless to light yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用机制

cell wall synthesis | interferes

储存温度

−20°C

SMILES string

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI key

DYDCUQKUCUHJBH-UWTATZPHSA-N

Gene Information

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

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一般描述

Chemical structure: amino acid derivatives

应用

D-cycloserine has been used to inhibit serine hydroxymethyltransferase.

生化/生理作用

作用方式：抑制细胞壁生物合成（D-Ala 肽键形成）。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Rick Richardson et al.
Learning & memory (Cold Spring Harbor, N.Y.), 11(5), 510-516 (2004-10-07)
Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of
Stefan G Hofmann et al.
The American journal of psychiatry, 170(7), 751-758 (2013-04-20)
The authors examined whether D-cycloserine, a partial agonist at the glutamatergic N-methyl-d-aspartate receptor, augments and accelerates a full course of comprehensive cognitive-behavioral therapy (CBT) in adults with generalized social anxiety disorder. This was a multisite randomized placebo-controlled efficacy study with
Marta Portero-Tresserra et al.
Neurobiology of learning and memory, 100, 1-11 (2012-12-04)
It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or
Michael Davis et al.
Biological psychiatry, 60(4), 369-375 (2006-08-22)
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with behavior therapy for the treatment of many anxiety disorders has generally lead to only modest gains. In this article we suggest that pharmacotherapy aimed not at treating the symptoms of
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