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Merck
CN

C3912

8-(4-氯苯硫基）-腺苷 3′,5′-环单磷酸 钠盐 钠盐

≥97.0% (HPLC), cAMP analog, powder

别名:

pCPT-cAMP

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关于此项目

经验公式（希尔记法）:
C16H14ClN5NaO6PS
化学文摘社编号:
93882-12-3
分子量:
493.79
NACRES:
NA.77
PubChem Substance ID:
24278024
UNSPSC Code:
41106305
EC Number:
299-413-9
MDL number:
MFCD00057683

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产品名称

8-(4-氯苯硫基）-腺苷 3′,5′-环单磷酸 钠盐 钠盐, ≥97.0% (HPLC), powder

InChI key

YIJFVHMIFGLKQL-DNBRLMRSSA-M

InChI

1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

assay

≥97.0% (HPLC)

form

powder

color

white

solubility

H2O: 25 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

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相关类别

Application

8-（4-硫代氯苯基）腺苷3′5′-环单磷酸用于：
  • 上调细胞胆固醇泵（三磷酸腺苷（ATP）结合盒（ABC）转运蛋白1，ABCA-1）
  • 葡萄糖生成测定
  • 刺激气道上皮细胞的囊性纤维化跨膜传导调节因子（CFTR）通道

Biochem/physiol Actions

膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶，在较高浓度时，抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌，但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。

Features and Benefits

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000493637
0000493636
0000493636
0000493637
0000486154

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Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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Product Information Sheet - C3912

Product Information Sheet

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