C4018
胆酰甘氨酸水解酶 来源于产气荚膜梭菌（韦氏梭菌）
lyophilized powder, ≥100 units/mg protein
别名:
3α,7α,12α-三羟基-5β-氯烷-24-甲酰甘氨酸酰胺水解酶
应用
来自 Sigma 的酶已在各种研究中用于胆汁样品的分析。
生化/生理作用
该酶是一种 N-末端亲核 (Ntn) 水解酶，催化酰胺键水解，从类固醇核心释放甘氨酸/牛磺酸部分，最终生成非结合胆汁酸。已证明可氧化巯基的药物（例如，对汞苯甲酸盐、碘乙酰胺、Hg 2 + 、Cu 2 + 和 Cd 2 + ）可强烈抑制 产气荚膜梭菌的胆盐水解酶 (BSH) 活性 。
外形
部分纯化的冻干粉末，含有缓冲盐和稳定剂
其他说明
一个单元将在37°C、pH 5.6 条件下5 min 内将 1.0μmol 甘胆酸水解为甘氨酸和胆酸。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Maksim Rossocha et al.
Biochemistry, 44(15), 5739-5748 (2005-04-13)
Bacterial bile salt hydrolases catalyze the degradation of conjugated bile acids in the mammalian gut. The crystal structures of conjugated bile acid hydrolase (CBAH) from Clostridium perfringens as apoenzyme and in complex with taurodeoxycholate that was hydrolyzed to the reaction
Effects of Quercetin and Rutin on Serum and Hepatic Lipid Concentrations, Fecal Steroid Excretion and Serum Antioxidant Properties
Nakamura Y, et al.
Journal of Health Science, 46(4), 229-240 (2000)
Bile salt hydrolase activity in probiotics.
Máire Begley et al.
Applied and environmental microbiology, 72(3), 1729-1738 (2006-03-07)
Christopher Martoni et al.
Applied microbiology and biotechnology, 81(2), 225-233 (2008-08-23)
This is the first study of its kind to screen probiotic lactic acid bacteria for the purpose of microencapsulating a highly bile salt hydrolase (BSH)-active strain. A Lactobacillus reuteri strain and a Bifidobacterium longum strain were isolated as the highest
Arekal N Roopashri et al.
Applied microbiology and biotechnology, 83(6), 1115-1126 (2009-05-02)
In a changing scenario of food habits being associated with wellness factors through the concepts of probiotics and prebiotics, an attempt has been made to characterize on molecular basis, the desirable benefits associated with natural isolates of lactic acid bacteria
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