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Merck
CN

C4032

酪蛋白，脱磷酸化 来源于牛奶

lyophilized powder

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关于此项目

化学文摘社编号:
9000-71-9
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130736
Form:
lyophilized powder
Assay:
≥85% (biuret)
Biological source:
bovine milk

主要文件

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产品名称

酪蛋白，脱磷酸化 来源于牛奶, lyophilized powder

SMILES string

[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

biological source

bovine milk

assay

≥85% (biuret)

form

lyophilized powder

UniProt accession no.

P02666
P02668

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... CSN2(281099), CSN3(281728)

Analysis Note

至少70%的去磷酸化。

Application

去磷酸化酪蛋白（来自牛乳）已用作体外激酶分析底物，包括拟南芥GSK3/Shaggy样激酶、酪蛋白激酶II和NIMA(never in mitosis A)-相关激酶2(Nek2)。

Biochem/physiol Actions

去磷酸化酪蛋白缺少一个净负电荷，对钙较不敏感。可用于食品行业。
酪蛋白中的磷酸丝氨酸簇可螯合铁并降低其生物利用度。酪蛋白的部分酶消化可将磷酸化的残基暴露给碱性磷酸酶，从而实现去磷酸化并提高铁的生物利用度。

General description

去磷酸化酪蛋白通过马铃薯酸性磷酸酶制成。溶解度更佳，发泡更少。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000483779
0000483779
0000320293
0000319016
0000265214

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Chen, Z., et al.
Proceedings of the National Academy of Sciences of the USA (2011)
Marie Lawson et al.
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We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and 2-bromoacetophenone which afforded final compound in only one step. The bioactivity
Functional Properties of Dephosphorylated Bovine Whole Casein1
Van Hekken DL and Strange, ED
Journal of Dairy Science, 76(11) (1993)
Wei Liu et al.
The Plant journal : for cell and molecular biology, 36(2), 189-202 (2003-10-11)
Casein kinases are critical in cell division and differentiation across species. A rice cDNA fragment encoding a putative casein kinase I (CKI) was identified via cDNA macroarray under brassinosteroid (BR) treatment, and a 1939-bp full-length cDNA, OsCKI1, was isolated and
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase.
Hirota T., et al.
PLoS Biology, 8 (2010)
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