SMILES string
[Na+].[Na+].CC(=O)N[C@@H](C=O)[C@@H](O[C@@H]1OC(=C[C@H](O)[C@H]1O)C([O-])=O)[C@@H](OS([O-])(=O)=O)[C@H](O)CO
InChI
1S/C14H21NO14S.2Na/c1-5(18)15-6(3-16)11(12(8(20)4-17)29-30(24,25)26)28-14-10(21)7(19)2-9(27-14)13(22)23;;/h2-3,6-8,10-12,14,17,19-21H,4H2,1H3,(H,15,18)(H,22,23)(H,24,25,26);;/q;2*+1/p-2/t6-,7-,8+,10+,11+,12-,14-;;/m0../s1
InChI key
DFRMXDKXNRVAFE-WBOKVGFFSA-L
assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white
solubility
H2O: soluble 10 mg/mL, clear, colorless
storage temp.
−20°C
General description
软骨素是一种糖胺聚糖(GAG)，是N-乙酰半乳糖胺(GalNAc)和葡萄糖醛酸(GlcA)交替单元组成的多糖链，可以在GalNAc和GlcA其中一个单元或两个单元上发生硫酸化。软骨素及其硫酸盐经常与蛋白质结合，形成蛋白多糖。
Application
软骨素二糖Δdi-4S可以作为底物，用于鉴定和表征酶，如产气荚膜梭菌（ Clostridium perfringens ）不饱和葡糖醛酸水解酶。在软骨素二糖硫酸盐的分析中，软骨素二糖Δdi-4S可用作参考化合物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Chondroitin sulfate: A key molecule in the brain matrix.
Kwok JC, Warren P, Fawcett JW.
The International Journal of Biochemistry & Cell Biology, 44(4), 582-586 (2011)
Yusuke Nakamichi et al.
The Journal of biological chemistry, 286(8), 6262-6271 (2010-12-15)
Pathogenic Streptococcus agalactiae produces polysaccharide lyases and unsaturated glucuronyl hydrolase (UGL), which are prerequisite for complete degradation of mammalian extracellular matrices, including glycosaminoglycans such as chondroitin and hyaluronan. Unlike the Bacillus enzyme, streptococcal UGLs prefer sulfated glycosaminoglycans. Here, we show
Glucosamine and chondroitin sulfate.
Miller KL, Clegg DO.
Rheumatic Diseases Clinics of North America, 23(1), 103-118 (2011)
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.
Galtrey CM, Fawcett JW.
Brain Research. Brain Research Reviews, 54, 1-18 (2007)
Kemal Solakyildirim et al.
Analytical biochemistry, 397(1), 24-28 (2009-09-23)
Chondroitin sulfate (CS) has an important role in cell division, in the central nervous system, and in joint-related pathologies such as osteoarthritis. Due to the complex chemical structure and biological importance of CS, simple, sensitive, high resolution, and robust analytical
商品
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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