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Merck
CN

C4124

氟化萘铬

≥98% (HPLC)

别名:

铬(pic) 3, CrPic

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关于此项目

经验公式(希尔记法):
C18H12CrN3O6
化学文摘社编号:
分子量:
418.30
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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biological source

synthetic

Quality Level

assay

≥98% (HPLC)

form

powder

loss

≤5% loss on drying

storage temp.

room temp

SMILES string

O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3

InChI

1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

InChI key

CBDQOLKNTOMMTL-UHFFFAOYSA-K

General description

吡啶甲酸铬是2型糖尿病的补充或替代药物,是抗胰岛素的3T3-L1脂肪细胞中CrPic的抗糖尿病机制。

Application

吡啶羧酸铬 (CrPic) 是一种膳食补充剂,可用于研究其作为葡萄糖摄取和胰岛素活性调节剂的潜力。CrPic用于研究其对动物体内核因子-κB(NF-κB)和核因子-E2相关因子-2(Nrf2)传递的影响。

Biochem/physiol Actions

吡啶甲酸铬(CrPic)是2型糖尿病的补充或替代药物。 实验证据表明,CrPic通过激活p38 MAPK对葡萄糖摄取产生影响。铬被认为可以增强胰岛素的作用,从而导致2型糖尿病的胰岛素敏感性增加。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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C P A van de Ligt et al.
Journal of animal science, 80(2), 483-493 (2002-03-09)
Two experiments were conducted to evaluate potential interactive effects of supplemental Cr and dietary energy supply in growing pigs. Experiment 1 used 36 individually penned barrows, 25 to 65 kg, in a 2 x 3 factorial arrangement of supplemental Cr
G W Evans et al.
Journal of inorganic biochemistry, 49(3), 177-187 (1993-02-15)
Coordination complexes of chromium (Cr) and two pyridine carboxylate isomers, nicotinate (nic) and picolinate (pic) were synthesized and analyzed. Cr mono and dinicotinate complexes were formed with 1:1 and 1:2 ratios of Cr3+ and nic at pH 7.5. Cr dinicotinate
J C Woodworth et al.
Domestic animal endocrinology, 26(1), 1-9 (2004-01-21)
Thirty-four sows (parity=1.8; BW=206 kg) were used to determine the influence of L-carnitine and/or chromium tripicolinate on plasma leptin concentrations of gestating sows fed one meal daily. Treatments were arranged in a 2 x 2 factorial with main effects of



全球贸易项目编号

货号GTIN
C4124-25G04061832407050
C4124-5G04061833491669