C4124
氟化萘铬
≥98% (HPLC)
别名:
铬(pic) 3, CrPic
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关于此项目
经验公式（希尔记法）:
C18H12CrN3O6
化学文摘社编号:
分子量:
418.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
生物来源
synthetic
质量水平
方案
≥98% (HPLC)
表单
powder
缺失
≤5% loss on drying
储存温度
room temp
SMILES字符串
O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3
InChI
1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
InChI key
CBDQOLKNTOMMTL-UHFFFAOYSA-K
一般描述
吡啶甲酸铬是2型糖尿病的补充或替代药物，是抗胰岛素的3T3-L1脂肪细胞中CrPic的抗糖尿病机制。
应用
吡啶羧酸铬 (CrPic) 是一种膳食补充剂，可用于研究其作为葡萄糖摄取和胰岛素活性调节剂的潜力。CrPic用于研究其对动物体内核因子-κB（NF-κB）和核因子-E2相关因子-2（Nrf2）传递的影响。
生化/生理作用
吡啶甲酸铬（CrPic）是2型糖尿病的补充或替代药物。 实验证据表明，CrPic通过激活p38 MAPK对葡萄糖摄取产生影响。铬被认为可以增强胰岛素的作用，从而导致2型糖尿病的胰岛素敏感性增加。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
J C Woodworth et al.
Domestic animal endocrinology, 26(1), 1-9 (2004-01-21)
Thirty-four sows (parity=1.8; BW=206 kg) were used to determine the influence of L-carnitine and/or chromium tripicolinate on plasma leptin concentrations of gestating sows fed one meal daily. Treatments were arranged in a 2 x 2 factorial with main effects of
C P A van de Ligt et al.
Journal of animal science, 80(2), 483-493 (2002-03-09)
Two experiments were conducted to evaluate potential interactive effects of supplemental Cr and dietary energy supply in growing pigs. Experiment 1 used 36 individually penned barrows, 25 to 65 kg, in a 2 x 3 factorial arrangement of supplemental Cr
G W Evans et al.
Journal of inorganic biochemistry, 49(3), 177-187 (1993-02-15)
Coordination complexes of chromium (Cr) and two pyridine carboxylate isomers, nicotinate (nic) and picolinate (pic) were synthesized and analyzed. Cr mono and dinicotinate complexes were formed with 1:1 and 1:2 ratios of Cr3+ and nic at pH 7.5. Cr dinicotinate
Influence of chromium picolinate on glucose usage and metabolic criteria in growing Holstein calves.
L D Bunting et al.
Journal of animal science, 72(6), 1591-1599 (1994-06-01)
Holstein calves, 10 steers (98 +/- 16 kg; Exp. 1) and 14 heifers (122 +/- 7 kg; Exp. 2), were fed either corn-cottonseed hull basal diets (CON; 15.1 and 13.2% CP, respectively) or CON plus 370 micrograms/kg of Cr as
T O Berner et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(6), 1029-1042 (2004-04-28)
Trivalent chromium is an essential element required for normal carbohydrate, lipid, and protein metabolism in humans and animals. This article describes how one particular form of trivalent chromium, chromium tripicolinate (Chromax), a stable complex of trivalent chromium and picolinic acid
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