C4238
CNS-1102
>98% (HPLC), solid
别名:
Aptiganel hydrochloride, Cerestat, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H21N3 · HCl
化学文摘社编号:
分子量:
339.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
CNS-1102, >98% (HPLC), solid
InChI key
CKAKVKWRMCAYJD-UHFFFAOYSA-N
SMILES string
Cl[H].CCc1cccc(c1)N(C)C(=N)Nc2cccc3ccccc23
InChI
1S/C20H21N3.ClH/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19;/h4-14H,3H2,1-2H3,(H2,21,22);1H
assay
>98% (HPLC)
form
solid
color
white
solubility
H2O: soluble 17 mg/mL
DMSO: soluble 20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CNS-1102 acts as a neuroprotective agent and might exhibit therapeutic effects against acute stroke and traumatic brain injury.
Noncompetitive NMDA glutamate receptor antagonist.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K W Muir et al.
Annals of the New York Academy of Sciences, 765, 279-289 (1995-09-15)
The high affinity noncompetitive N-methyl-D-aspartate receptor antagonist CNS 1102 (aptiganel hydrochloride, Cambridge NeuroScience, Cambridge, MA.) is neuroprotective in preclinical models of stroke when administered as pretreatment or up to 60 minutes postischemia, and has potential for treatment of acute stroke
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